Mid-Atlantic (VISN 6) Mental Illness Research, Education, and Clinical Center (MIRECC), Salisbury VA Healthcare System, Salisbury, NC, USA.
Department of Neurology, Wake Forest School of Medicine, Winston Salem, NC, USA.
Arch Clin Neuropsychol. 2021 Jul 19;36(5):850-856. doi: 10.1093/arclin/acaa119.
The study objective was to determine whether number of concussions would affect symptom improvement following cognitive rehabilitation (CR) interventions.
Service members (N = 126) with concussion history completed a 6-week randomized control trial of CR interventions. Participants were stratified based on self-reported lifetime concussion frequency. Outcome measures included the Paced Auditory Serial Addition Test (PASAT), the Global Severity Index (GSI) from the Symptom Checklist-90-Revised, and the Key Behaviors Change Inventory (KBCI).
Mixed-model analyses of variance revealed a significant main effect for time on cognitive, psychological, and neurobehavioral functioning. A significant main effect for the number of concussions was observed for GSI and KBCI, but not PASAT. Interactions between the number of concussions and time were not significant for any of the outcome variables.
Over the 6-week interval, improvements were found for all participants across all outcome measures. Number of concussions did not affect improvements over time.
本研究旨在确定脑震荡次数是否会影响认知康复（CR）干预后的症状改善。
有脑震荡病史的军人（N=126）完成了为期 6 周的 CR 干预随机对照试验。参与者根据自我报告的终身脑震荡频率进行分层。结局测量包括听觉连续加法测试（PASAT）、症状清单-90 修订版的全球严重程度指数（GSI）和关键行为变化量表（KBCI）。
方差混合模型分析显示，认知、心理和神经行为功能在时间上有显著的主效应。GSI 和 KBCI 有显著的脑震荡次数主效应，但 PASAT 没有。在任何结局变量中，脑震荡次数和时间之间的交互作用均不显著。
在 6 周的时间内，所有参与者在所有结局测量上都有改善。脑震荡次数并未影响随时间的改善。
