Xu Yifan, He Yuxin, Xu Wu, Lu Tianyu, Liang Weibang, Jin Wei
Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Department of Neurosurgery, Nanjing 210000, Jiangsu Province, P. R. China.
Ideggyogy Sz. 2020 Nov 30;73(11-12):399-403. doi: 10.18071/isz.73.0399.
Background - Up to now, the risk factors related to intracranial infections after transsphenoidal pituitary adenomectomy remain controversial. Purpose - To analyze the risk factors related to intracranial infections after transsphenoidal pituitary adenomectomy under an endoscope, and to provide evidence for preventing and controlling the occurrence and development of infections.
A total of 370 patients receiving endoscopic transsphenoidal pituitary adenomectomy in our hospital from January 2014 to October 2017 were selected. The risk factors related to postoperative intracranial infections were analyzed. The hospitalization lengths and expenditures of patients with and without intracranial infections were compared.
Of the 370 patients, 18 underwent postoperative intracranial infections, with the infection rate of 4.86%. Intraoperative blood loss >120 mL, cerebrospinal leakage, diabetes, preoperative use of hormones, macroadenoma as well as surgical time >4 h all significantly increased the infection rate (P<0.05). Preoperative use of antibacterial agents prevented intracranial infection. Compared with patients without intracranial infections, the infected ones had significantly prolonged hospitalization length and increased expenditure (P<0.05). Discussion - It is of great clinical significance to analyze the risk factors related to intracranial infection after endoscopic transsphenoidal pituitary adenomectomy, aiming to prevent and to control the onset and progression of infection.
Intracranial infections after endoscopic transsphenoidal pituitary adenomectomy were affected by many risk factors, also influencing the prognosis of patients and the economic burden.
背景——迄今为止，经蝶窦垂体腺瘤切除术后颅内感染的相关危险因素仍存在争议。目的——分析内镜下经蝶窦垂体腺瘤切除术后颅内感染的相关危险因素，为预防和控制感染的发生与发展提供依据。
选取2014年1月至2017年10月在我院接受内镜下经蝶窦垂体腺瘤切除术的370例患者。分析术后颅内感染的相关危险因素。比较有无颅内感染患者的住院时间和费用。
370例患者中，18例术后发生颅内感染，感染率为4.86%。术中失血量>120 mL、脑脊液漏、糖尿病、术前使用激素、大腺瘤以及手术时间>4 h均显著增加感染率（P<0.05）。术前使用抗菌药物可预防颅内感染。与无颅内感染的患者相比，感染患者的住院时间显著延长，费用增加（P<0.05）。讨论——分析内镜下经蝶窦垂体腺瘤切除术后颅内感染的相关危险因素对于预防和控制感染的发生与发展具有重要临床意义。
内镜下经蝶窦垂体腺瘤切除术后颅内感染受多种危险因素影响，也影响患者预后及经济负担。
