Department of Chemistry and Center for NanoScience, Ludwig-Maximilians-Universität München, 80539 München, Germany.
Structure. 2020 Dec 1;28(12):1269-1270. doi: 10.1016/j.str.2020.11.009.
Single-molecule experiments reveal structure function relationships and biomolecular dynamics in physiologically relevant conditions. In this issue of Structure, Park et al. (2020) report an optimized surface passivation strategy with polyethylene glycol in a dense, contracted conformation. Assembly of a functional transcription pre-initiation complex is demonstrated.
单分子实验揭示了生理相关条件下的结构与功能关系和生物分子动力学。在本期结构杂志中，Park 等人（2020）报道了一种优化的表面钝化策略，使用高密度、收缩构象的聚乙二醇。功能性转录起始前复合物的组装得到了证实。
