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下丘脑神经酰胺与卵巢交感神经系统：肥胖与青春期的交汇点。

Hypothalamic Ceramides and the Ovarian Sympathetic System: At the Crossroads of Obesity and Puberty.

机构信息

Harvard MGH Center for Reproductive Medicine and Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA.

Harvard MGH Center for Reproductive Medicine and Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA.

出版信息

Cell Metab. 2021 Jan 5;33(1):6-8. doi: 10.1016/j.cmet.2020.11.012. Epub 2020 Dec 1.

DOI:10.1016/j.cmet.2020.11.012
PMID:33264644
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8939237/
Abstract

Childhood obesity has been linked to early puberty in girls but the mechanism(s) by which overnutrition triggers pubertal onset remain unclear. In a recent issue of Cell Metabolism, Heras et al., 2020 implicate a non-canonical central ceramide to ovarian sympathetic innervation pathway as a novel mediator of obesity-induced pubertal acceleration in female rats.

摘要

儿童肥胖与女孩青春期提前有关，但营养过剩引发青春期开始的确切机制仍不清楚。在最近一期的《细胞代谢》杂志上，Heras 等人表明，非经典的中枢神经酰胺到卵巢交感神经支配途径是肥胖诱导雌性大鼠青春期加速的一个新的介质。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51e5/8939237/891bcde472b8/nihms-1773648-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51e5/8939237/891bcde472b8/nihms-1773648-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51e5/8939237/891bcde472b8/nihms-1773648-f0001.jpg

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本文引用的文献

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Central Ceramide Signaling Mediates Obesity-Induced Precocious Puberty.中央神经酰胺信号介导肥胖诱导的性早熟。
Cell Metab. 2020 Dec 1;32(6):951-966.e8. doi: 10.1016/j.cmet.2020.10.001. Epub 2020 Oct 19.
2
Connections Between Obesity and Puberty: Invited by Manuel Tena-Sempere, Cordoba.肥胖与青春期之间的联系：由科尔多瓦的曼努埃尔·特纳 - 森佩雷邀请
Curr Opin Endocr Metab Res. 2020 Oct;14:160-168. doi: 10.1016/j.coemr.2020.08.004. Epub 2020 Aug 27.
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Metabolic regulation of kisspeptin - the link between energy balance and reproduction.代谢调节 kisspeptin-能量平衡与生殖的联系。
Nat Rev Endocrinol. 2020 Aug;16(8):407-420. doi: 10.1038/s41574-020-0363-7. Epub 2020 May 19.
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Animal Models to Understand the Etiology and Pathophysiology of Polycystic Ovary Syndrome.用于理解多囊卵巢综合征病因和病理生理学的动物模型
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Novel mechanisms for the metabolic control of puberty: implications for pubertal alterations in early-onset obesity and malnutrition.青春期代谢调控的新机制：对早发性肥胖和营养不良青春期改变的启示。
J Endocrinol. 2019 Aug;242(2):R51-R65. doi: 10.1530/JOE-19-0223.
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Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.母源来源特异性等位基因关联在 106 个基因组位点与初潮年龄相关。
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