瘢痕性结膜炎作为原发性干燥综合征的一种不常见表现。
Cicatrizing conjunctivitis as an uncommon manifestation of primary Sjögren's syndrome.
机构信息
Department of Ophthalmology, Rabin Medical Center, Petah-Tikva, Israel; Metropolitan Eye Research and Surgery Institute, Palisades Park, NJ, USA.
Ocular Surface Diseases and Dry Eye Clinic, Division of Cornea and External Diseases, The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
出版信息
Ocul Surf. 2021 Jan;19:38-42. doi: 10.1016/j.jtos.2020.11.014. Epub 2020 Nov 29.
PURPOSE
To report occurrence of cicatrizing conjunctivitis as an extraglandular ocular manifestation of primary Sjögren's syndrome (SS).
METHODS
Medical charts of all patients with SS evaluated at two tertiary ophthalmological referral centers were reviewed. Patients who demonstrated clinical findings of cicatrizing conjunctivitis were included in this review. Patient and disease-related data including ocular complications, therapies and outcomes were collected.
RESULTS
Eight patients with a diagnosisis of SS were noted to have cicatrizing conjunctivitis findings over a period of 11 years (between 2009 and 2020). Mean age of patients was 79. All patients had a negative immunoreactant deposition in conjunctival biopsy. Mean follow-up time was 6 years (range, 18-197 months). Three patients had progression of conjunctival scarring. Worsening of vision occurred in 4 patients due to corneal complications, including ulceration, perforation and scarring.
CONCLUSIONS
SS is an under-recognized etiology of severe progressive cicatrizing conjunctivitis that can lead to ocular morbidity and loss of vision without appropriate management.
目的
报告原发性干燥综合征（SS）的一种眼外器官表现——瘢痕性结膜炎的发病情况。
方法
回顾了在两个三级眼科转诊中心评估的所有 SS 患者的病历。本回顾纳入了表现出瘢痕性结膜炎临床特征的患者。收集了患者和疾病相关数据，包括眼部并发症、治疗方法和结果。
结果
在 11 年期间（2009 年至 2020 年），8 例 SS 患者被诊断为存在瘢痕性结膜炎表现。患者的平均年龄为 79 岁。所有患者的结膜活检均未发现免疫反应物沉积。平均随访时间为 6 年（范围 18-197 个月）。3 例患者的结膜瘢痕出现进展。4 例患者因角膜并发症（包括溃疡、穿孔和瘢痕形成）导致视力恶化。
结论
SS 是一种严重进行性瘢痕性结膜炎的认识不足的病因，如果不进行适当的治疗，可能会导致眼部发病率和视力丧失。
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