Carbone Maria Vittoria, Cavaliere Anna Franca, Fedele Camilla, Vidiri Annalisa, Aciuolo Damiano, Zannoni Gianfranco, Scambia Giovanni
Department of Woman and Child Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Italy.
Department of Woman and Child Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Italy; Università Cattolica del Sacro Cuore, Rome, Italy.
Eur J Obstet Gynecol Reprod Biol. 2021 Jan;256:326-332. doi: 10.1016/j.ejogrb.2020.11.043. Epub 2020 Nov 17.
Uterine tumor resembling ovarian sex-cord tumor (UTROSCT) is a rare distinct cancer included in the current World Health Organization classification of endometrial stromal tumors. A battery of immunohistochemical markers are necessary for accurate diagnosis. Although few case reports and case series have been documented and therefore providing robust prognostic information several authors agree to consider UTROSCT as a low malignant potential tumour. In literature only five cases of conservative management were reported. We reported our experience and a review of conservative cases of literature. In this article we describe a series of 10 cases of UTROSCT and their clinical and pathologic feature. We report two cases of conservative surgical approach obtaining a successfully pregnancies. All of the patients are still alive. In conclusion, fertility sparing surgery should be offered to patients who wish preserve their fertility however radical surgery must be considerate after childbirth. Close follow-up is required for all patients due to the lack of prognostic biomarkers and long follow up is needed to evaluate safety of conservative surgery.
子宫肿瘤样卵巢性索肿瘤（UTROSCT）是一种罕见的独特癌症，被纳入世界卫生组织当前的子宫内膜间质肿瘤分类中。准确诊断需要一系列免疫组化标志物。尽管已有少数病例报告和病例系列记录，但由于提供的可靠预后信息较少，几位作者同意将UTROSCT视为低恶性潜能肿瘤。文献中仅报道了5例保守治疗的病例。我们报告了我们的经验并回顾了文献中的保守治疗病例。在本文中，我们描述了一系列10例UTROSCT病例及其临床和病理特征。我们报告了2例采用保守手术方法并成功妊娠的病例。所有患者均存活。总之，对于希望保留生育能力的患者应提供保留生育功能的手术，但产后必须考虑进行根治性手术。由于缺乏预后生物标志物，所有患者都需要密切随访，并且需要长期随访以评估保守手术的安全性。
