（2,3）-亚甲基青霉烷对细菌外膜的穿透作用
Outer membrane penetration by (2,3)-methylenepenams.
作者信息
Chapman J S, Georgopapadakou N H
机构信息
Roche Research Center, Nutley, New Jersey 07110.
出版信息
Antimicrob Agents Chemother. 1987 Dec;31(12):1994-6. doi: 10.1128/AAC.31.12.1994.
Abstract
The penetration of the Escherichia coli outer membrane by two sterically restricted analogs of penicillin G was determined. The analog corresponding to the "open" conformation of penicillin G penetrated faster than the "closed"-form analog did, and both analogs penetrated faster than penicillin G did. The results suggest that the conformation of the beta-lactam nucleus may affect penetrability via the porin-mediated pathway.
摘要
测定了两种空间位阻受限的青霉素G类似物对大肠杆菌外膜的穿透情况。与青霉素G“开放”构象相对应的类似物比“封闭”构象类似物穿透得更快，且这两种类似物都比青霉素G穿透得更快。结果表明，β-内酰胺核的构象可能通过孔蛋白介导的途径影响穿透性。
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引用本文的文献
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Biochem J. 1965 Mar;94(3):666-75. doi: 10.1042/bj0940666.
2
Effect on solute size on diffusion rates through the transmembrane pores of the outer membrane of Escherichia coli.溶质大小对通过大肠杆菌外膜跨膜孔扩散速率的影响。
J Gen Physiol. 1981 Feb;77(2):121-35. doi: 10.1085/jgp.77.2.121.
3
Role of porin proteins OmpF and OmpC in the permeation of beta-lactams.孔蛋白OmpF和OmpC在β-内酰胺通透性中的作用。
Antimicrob Agents Chemother. 1982 Dec;22(6):942-8. doi: 10.1128/AAC.22.6.942.
4
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J Bacteriol. 1983 Jan;153(1):232-40. doi: 10.1128/jb.153.1.232-240.1983.
5
Alterations in outer membrane permeability.外膜通透性的改变。
Annu Rev Microbiol. 1984;38:237-64. doi: 10.1146/annurev.mi.38.100184.001321.
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