Takesawa S, Ohashi H, Hidai H, Sakai K
Department of Chemical Engineering, Waseda University, Tokyo, Japan.
Artif Organs. 1987 Dec;11(6):495-7. doi: 10.1111/j.1525-1594.1987.tb02716.x.
Much attention is being devoted to the efficient removal of beta 2-microglobulin from patients on hemodialysis as it may cause amyloidosis. The objective of the present article is to clarify the beta 2-microglobulin removal characteristics of dialysis membranes having varying water contents and pore radii. For membranes of regenerated cellulose, polymethylmethacrylate (PMMA) and ethylenevinyl alcohol (EVA), solute and pure water permeability and water content were determined by the standard methods. Data analysis using a tortuous pore model allows determination of pore radius, surface porosity, and tortuosity, and hence, the sieving coefficient as a function of Stokes radius. Based on the tortuous pore model calculation, little beta 2-microglobulin is removed from patients on hemodialysis by regenerated cellulose and PMMA membranes, but EVA membranes, with a sieving coefficient of 0.5, are capable of removing it. The solute permeability for urea is about 2 orders greater than that for beta 2-microglobulin.
由于β2-微球蛋白可能导致淀粉样变性，目前人们非常关注如何有效地从血液透析患者体内清除该物质。本文的目的是阐明具有不同含水量和孔径的透析膜对β2-微球蛋白的清除特性。对于再生纤维素、聚甲基丙烯酸甲酯（PMMA）和乙烯-乙烯醇（EVA）膜，采用标准方法测定了溶质和纯水渗透率以及含水量。使用曲折孔模型进行数据分析，可以确定孔径、表面孔隙率和曲折度，从而确定筛分系数与斯托克斯半径的函数关系。基于曲折孔模型计算，再生纤维素和PMMA膜对血液透析患者体内β2-微球蛋白的清除量很少，但筛分系数为0.5的EVA膜能够清除该物质。尿素的溶质渗透率比β2-微球蛋白的溶质渗透率大约高2个数量级。
