高血压患者阻力血管结构变化的可逆性：心得静研究综述
Reversibility of structural changes in the resistance vessels in hypertension: a review of studies with pindolol.
作者信息
Duner H
机构信息
Department of Internal Medicine, Sabbatsberg Hospital, Stockholm, Sweden.
出版信息
Br J Clin Pharmacol. 1987;24 Suppl 1(Suppl 1):51S-54S. doi: 10.1111/j.1365-2125.1987.tb03269.x.
Abstract
- In recent years evidence has accumulated which indicates that although various beta-adrenoceptor antagonists are equally effective in lowering blood pressure in patients with essential hypertension the mechanisms of action of the different drugs are heterogeneous. 2. Pindolol, a beta-adrenoceptor antagonist with pronounced intrinsic sympathomimetic activity (ISA) appears, to some extent, to act via peripheral vascular mechanisms. 3. Following prolonged treatment with pindolol in essential hypertension peripheral vascular resistance at maximal vasodilatation has been found to be decreased compared with the pretreatment values suggesting that the structural vascular changes characteristic of established hypertension may be reversible.
摘要
- 近年来，越来越多的证据表明，尽管各种β-肾上腺素能受体拮抗剂在降低原发性高血压患者血压方面同样有效，但不同药物的作用机制是异质性的。2. 吲哚洛尔是一种具有明显内在拟交感活性（ISA）的β-肾上腺素能受体拮抗剂，在一定程度上似乎是通过外周血管机制起作用的。3. 在原发性高血压患者中，用吲哚洛尔进行长期治疗后，发现最大血管舒张时的外周血管阻力与治疗前值相比有所降低，这表明已确立的高血压所特有的结构性血管变化可能是可逆的。
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本文引用的文献
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Hemodynamic effect of long--term treatment with pindolol in essential hypertension with special reference to the resistance and capacitance vessels of the forearm.
Acta Med Scand. 1977;202(6):517-21. doi: 10.1111/j.0954-6820.1977.tb16874.x.
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