School of Medicine, University of Auckland, Auckland 1023, New Zealand.
Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore 117609, Singapore.
Nutrients. 2020 Nov 22;12(11):3579. doi: 10.3390/nu12113579.
Dietary intake of iron is known to be associated with impaired glucose metabolism. However, its involvement in derangements of glucose metabolism after acute pancreatitis (AP) is not completely understood. The aim was to investigate the association between dietary iron intake and markers of glucose metabolism in individuals after an attack of AP. Fasting blood samples were collected to analyse markers of glucose metabolism (fasting plasma glucose (FPG) and haemoglobin A1c (HbA1c)). The EPIC-Norfolk food frequency questionnaire was used to determine the habitual intake of dietary iron (total, haem, and non-haem). Multivariable linear regression analyses were conducted and six statistical models were built to adjust for covariates. A total of 109 individuals after AP were studied in a cross-sectional fashion. Total iron (β (95% confidence interval) = -0.19 (-0.35, -0.05); = 0.01 in the most adjusted model) and non-haem iron (β (95% confidence interval) = -0.19 (-0.33, -0.04); = 0.03 in the most adjusted model) were significantly associated with FPG, consistently in all adjusted model. Total iron and non-haem iron did not have consistent significant associations with HbA1c. Dietary haem iron intake was not associated with either FPG or HbA1c. Habitual intake of dietary iron is inversely associated with FPG in individuals after an attack of AP and may be involved in the pathogenesis of new-onset diabetes after pancreatitis. Prospective longitudinal studies are now warranted to unveil the specific mechanism underlying the involvement of dietary iron.
已知铁的饮食摄入量与葡萄糖代谢受损有关。然而，其在急性胰腺炎（AP）后葡萄糖代谢紊乱中的作用尚不完全清楚。目的是研究 AP 发作后个体的膳食铁摄入量与葡萄糖代谢标志物之间的关系。采集空腹血样以分析葡萄糖代谢标志物（空腹血糖（FPG）和糖化血红蛋白（HbA1c））。使用 EPIC-Norfolk 食物频率问卷来确定膳食铁的习惯性摄入量（总铁、血红素铁和非血红素铁）。进行了多变量线性回归分析，并建立了六个统计模型来调整协变量。以横断面方式研究了 109 名 AP 后个体。总铁（β（95%置信区间）=-0.19（-0.35，-0.05）；在最调整模型中 = 0.01）和非血红素铁（β（95%置信区间）=-0.19（-0.33，-0.04）；在最调整模型中 = 0.03）与 FPG 显著相关，在所有调整模型中均一致。总铁和非血红素铁与 HbA1c 没有一致的显著关联。膳食血红素铁的摄入量与 FPG 或 HbA1c 均无关联。AP 发作后个体的膳食铁摄入量与 FPG 呈负相关，可能与胰腺炎后新发糖尿病的发病机制有关。现在需要进行前瞻性纵向研究，以揭示膳食铁参与的具体机制。
