School of Medicine, University of Auckland, Auckland, New Zealand.
School of Medicine, University of Auckland, Auckland, New Zealand.
Clin Chim Acta. 2020 Dec;511:167-176. doi: 10.1016/j.cca.2020.10.013. Epub 2020 Oct 13.
Although the pathophysiological mechanisms and consequences of gross derangements in iron metabolism are well known, little is known about the pathophysiological mechanisms underlying mild-to-moderate alterations in iron metabolism and their consequences. Growing evidence indicates that the exocrine pancreas has a bidirectional relationship with iron metabolism. Studies have shown alterations in circulating markers of iron metabolism, iron absorption, and intra-pancreatic iron deposition in pancreatitis. At the same time, exocrine pancreatic dysfunction has been shown in iron overload disorders. These observations reveal a compelling connection between the exocrine pancreas and iron metabolism, which are further elucidated by observations of therapeutic benefits of iron chelating agents and pancreatic enzyme replacement therapy. While the pancreas is not a major reservoir of iron in the body, better understanding of its relationship with iron metabolism may yield unexpected insights.
虽然铁代谢严重紊乱的病理生理机制和后果众所周知，但对于铁代谢轻度至中度改变的病理生理机制及其后果知之甚少。越来越多的证据表明，外分泌胰腺与铁代谢之间存在双向关系。研究表明，在胰腺炎中，循环铁代谢标志物、铁吸收和胰腺内铁沉积发生改变。同时，铁过载疾病中外分泌胰腺功能障碍也已被证实。这些观察结果揭示了外分泌胰腺和铁代谢之间的紧密联系，而铁螯合剂和胰腺酶替代疗法的治疗益处的观察进一步阐明了这一点。虽然胰腺不是体内铁的主要储存库，但对外分泌胰腺与铁代谢关系的更好理解可能会带来意想不到的启示。
