Nishikawa A, Nakamura Y, Nobori U, Aoki T, Higashino H, Matsui T, Kobayashi Y, Yamashita M, Unishi G
Department of Pediatrics, Kansai Medical University, Osaka, Japan.
Cancer. 1987 Nov 1;60(9):2146-9. doi: 10.1002/1097-0142(19871101)60:9<2146::aid-cncr2820600904>3.0.co;2-n.
Three patients were studied: two infants with acute monocytic leukemia who failed to respond to the initial combination therapy of daunorubicin with cytosine arabinoside, and an adolescent with relapsed acute monocytic leukemia. They were intensively treated with epipodophyllotoxin (VP-16-213) alone and subsequently had complete remission. One patient showed apparently dose-dependent cytotoxic effect. All three patients have maintained complete remission for 6, 7, and 11 months, respectively. Toxicities, including myelosuppression, alopecia, nausea, vomiting, and renal dysfunction, were well tolerated. Intensive treatment with VP-16-213 alone was thus found to have a potent therapeutic effect on acute monocytic leukemia in children. VP-16-213 deserves a further assessment in the therapeutic protocol for patients with childhood acute monocytic leukemia.
两名患有急性单核细胞白血病的婴儿，对柔红霉素与阿糖胞苷的初始联合治疗无反应，以及一名复发性急性单核细胞白血病的青少年。他们单独接受了足叶乙毒素（VP-16-213）的强化治疗，随后完全缓解。一名患者显示出明显的剂量依赖性细胞毒性作用。所有三名患者分别维持完全缓解6个月、7个月和11个月。包括骨髓抑制、脱发、恶心、呕吐和肾功能障碍在内的毒性反应耐受性良好。因此发现单独使用VP-16-213进行强化治疗对儿童急性单核细胞白血病有显著疗效。VP-16-213值得在儿童急性单核细胞白血病患者的治疗方案中进行进一步评估。
