Tang Juan, Chen Xue, Zhao Chao-Qun, Li Wen-Jing, Li Shun, Zheng Xue-Li, Yuan Mao-Lin, Fu Hai-Yan, Li Rui-Xiang, Chen Hua
Key lab of Green Chemistry and Technology, Ministry of Education; College of Chemistry, Sichuan University, Chengdu 610064, People's Republic of China.
J Org Chem. 2021 Jan 1;86(1):716-730. doi: 10.1021/acs.joc.0c02321. Epub 2020 Dec 2.
The NaIO-mediated sequential iodination/amidation reaction of -alkyl quinolinium iodide salts has been first developed. This cascade process provides an efficient way to rapidly synthesize 3-iodo--alkyl quinolinones with high regioselectivity and good functional group tolerance. This protocol was also amenable to the isoquinolinium salts, thus providing a complementary method for preparing the 4-iodo--alkyl isoquinolinones.
首次开发了NaIO介导的α-烷基喹啉碘盐的顺序碘化/酰胺化反应。这一级联过程提供了一种高效的方法，能够以高区域选择性和良好的官能团耐受性快速合成3-碘-α-烷基喹啉酮。该方法也适用于异喹啉盐，从而为制备4-碘-α-烷基异喹啉酮提供了一种补充方法。
