Iaina A, Thomsen K, Goldfarb D, Serban I, Gavendo S, Kapuler S, Lusky A, Eliahou H E
Department of Nephrology, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
Isr J Med Sci. 1987 Dec;23(12):1205-9.
The relationship between plasma renin activity and distal tubular sodium delivery and reabsorption was examined in man. Distal sodium delivery and reabsorption were measured during hypotonic volume expansion by the free water clearance method, or during hydropenia or isotonic volume expansion by the lithium clearance method. The maximal water diuresis method and the lithium clearance method both showed a negative correlation between plasma renin activity and distal sodium delivery and reabsorption. Only with the lithium clearance method, however, was it possible to measure plasma renin activity, distal sodium delivery and reabsorption in hydropenia without disturbances of water and electrolyte balance and plasma renin activity level. In hydropenia the plasma renin activity was higher and the fractional distal sodium delivery and reabsorption lower than during volume expansion. Our results support the idea that sodium chloride reabsorption at the macula densa region is negatively correlated to the plasma renin activity in man.
在人体中研究了血浆肾素活性与远端肾小管钠输送及重吸收之间的关系。通过自由水清除率法在低渗性容量扩张期间，或通过锂清除率法在缺水或等渗性容量扩张期间测量远端钠输送及重吸收。最大水利尿法和锂清除率法均显示血浆肾素活性与远端钠输送及重吸收之间呈负相关。然而，只有采用锂清除率法，才能够在不干扰水和电解质平衡及血浆肾素活性水平的情况下，在缺水状态下测量血浆肾素活性、远端钠输送及重吸收。在缺水状态下，血浆肾素活性较高，而远端钠的分数输送及重吸收低于容量扩张期间。我们的结果支持这样一种观点，即人体致密斑区域的氯化钠重吸收与血浆肾素活性呈负相关。
