National Hospital Organization, Kyoto Medical Center, Kyoto, Japan.
START-program, Japan Science and Technology Agency (JST), Tokyo, Japan.
Br J Cancer. 2021 Feb;124(4):681-682. doi: 10.1038/s41416-020-01183-y. Epub 2020 Dec 3.
During treatment, the development of drug-resistant tumours remains an important challenge in cancer treatment. Epigenetic changes have been reported as one of the mechanisms for anti-tumour drug resistance. In clinical practice, a combination of epigenetic-related drugs can be considered as a future selection of cancer therapeutic drugs.
在治疗过程中,耐药肿瘤的发展仍然是癌症治疗中的一个重要挑战。据报道,表观遗传变化是抗肿瘤药物耐药性的机制之一。在临床实践中,可以考虑将与表观遗传相关的药物联合作为癌症治疗药物的未来选择。