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一名部分接种疫苗男孩的白喉与传染性单核细胞增多症合并感染病例。

A Case of Diphtheria and Infectious Mononucleosis Co-Infection in a Partially Vaccinated Boy.

作者信息

Cyril Gladys, Rathish Balram, Wilson Arun, Warrier Anup, Viswam Vineeth

机构信息

Pediatrics, Aster Medcity, Kochi, IND.

Infectious Diseases, Aster Medcity, Kochi, IND.

出版信息

Cureus. 2020 Oct 28;12(10):e11227. doi: 10.7759/cureus.11227.

DOI:10.7759/cureus.11227
PMID:33269155
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7704157/
Abstract

We report the case of an eight-year-old partially immunized boy who presented with presumed bacterial tonsillitis. He was initially prescribed amoxicillin-clavulanic acid which resulted in the development of an erythematous maculopapular over the face which spread to the trunk and extremities including palms and soles and resolved over the next three days. He was diagnosed to have diphtheria and infectious mononucleosis (IMN) co-infection. He made an uneventful recovery and an extensive review of the literature showed that the incidence of diphtheria and IMN co-infection is a relatively rare clinical entity. We wish to highlight the possibility of such co-infections which often mimic one another.

摘要

我们报告了一例8岁的部分免疫接种男孩的病例,该男孩表现为疑似细菌性扁桃体炎。他最初被开了阿莫西林 - 克拉维酸,用药后脸部出现红斑性斑丘疹,随后蔓延至躯干和四肢,包括手掌和脚底,并在接下来的三天内消退。他被诊断为白喉和传染性单核细胞增多症(IMN)合并感染。他康复过程顺利,对文献的广泛回顾显示,白喉和IMN合并感染的发生率是一种相对罕见的临床情况。我们希望强调这种合并感染的可能性,因为它们常常相互模仿。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cdb/7704157/5dfd63bbc0ef/cureus-0012-00000011227-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cdb/7704157/4bdaba597814/cureus-0012-00000011227-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cdb/7704157/28866b5acd37/cureus-0012-00000011227-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cdb/7704157/5dfd63bbc0ef/cureus-0012-00000011227-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cdb/7704157/4bdaba597814/cureus-0012-00000011227-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cdb/7704157/28866b5acd37/cureus-0012-00000011227-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cdb/7704157/5dfd63bbc0ef/cureus-0012-00000011227-i03.jpg

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本文引用的文献

1
Amoxicillin rash in patients with infectious mononucleosis: evidence of true drug sensitization.传染性单核细胞增多症患者的阿莫西林皮疹:真正药物致敏的证据。
Allergy Asthma Clin Immunol. 2015 Jan 9;11(1):1. doi: 10.1186/1710-1492-11-1. eCollection 2015.
2
Concurrent diphtheria and infectious mononucleosis: difficulties for management, investigation and control of diphtheria in developing countries.同时患有白喉和传染性单核细胞增多症:发展中国家对白喉进行管理、调查和控制的困难。
J Med Microbiol. 2011 Nov;60(Pt 11):1685-1688. doi: 10.1099/jmm.0.027870-0. Epub 2011 Jun 16.
3
When Infections Co-exist: Infectious Mono and Diphtheria.
当感染同时存在时:传染性单核细胞增多症和白喉。
Can Fam Physician. 1982 Apr;28:785-8.
4
Investigations and control measures following a non-travel-associated case of toxigenic Cornyebacterium diphtheriae, London, United Kingdom, December 2009-January 2010.英国伦敦 2009 年 12 月至 2010 年 1 月,一起非旅行相关的产毒白喉棒状杆菌病例的调查和控制措施。
Euro Surveill. 2010 Apr 22;15(16):19544.