Bühler F R, Kiowski W
Division of Cardiology, University Hospital, Kantonsspital Basel.
J Hypertens Suppl. 1987 Dec;5(4):S111-4. doi: 10.1097/00004872-198712004-00017.
Calcium antagonists are being increasingly used for the treatment of hypertension. Analysis of response patterns shows that they are particularly effective in older, low-renin and black patients. Although the reasons for this pattern are not quite clear there is evidence that the attenuated cardiovascular reflex responses may be important in these groups. Baroreflex responses are blunted in older subjects and even more so in older hypertensive patients. Patients with low-renin hypertension also show impaired sympathetic nervous system response and black subjects often have low renin levels. A diminished counter-regulatory response to the vasodilating effects of calcium antagonists may partly explain the good clinical responses of older, low-renin and black patients.
钙拮抗剂正越来越多地用于治疗高血压。对反应模式的分析表明，它们在老年、低肾素和黑人患者中特别有效。尽管这种模式的原因尚不完全清楚，但有证据表明，心血管反射反应减弱在这些人群中可能很重要。压力反射反应在老年受试者中减弱，在老年高血压患者中更是如此。低肾素性高血压患者也表现出交感神经系统反应受损，而黑人受试者的肾素水平通常较低。对钙拮抗剂血管舒张作用的反调节反应减弱可能部分解释了老年、低肾素和黑人患者良好的临床反应。
