P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia.
Bull Exp Biol Med. 2020 Dec;170(2):175-180. doi: 10.1007/s10517-020-05027-w. Epub 2020 Dec 3.
We studied the involvement of NMDA glutamate receptors in the mechanisms of anterograde amnesia. It was found that repeated training of amnestic animals treated with D-cycloserine, a potent agonist of the glycine site of NMDA receptors, did not lead to consolidation of long-term memory, while expression of short-term memory was more pronounced in comparison with control animals that received saline before repeated training. It was shown that D-cycloserine in amnestic snails did not affect the food reactions caused by the presentation of a conditioned stimulus during the reminder (without combination with the unconditioned stimulus). It is assumed that NMDA glutamate receptors in amnestic animals are involved in the neural plasticity mechanisms that underlie short-term memory, but their activation does not influence the anterograde amnesia processes and does not lead to the formation or recovery of long-term memory.
我们研究了 NMDA 谷氨酸受体在顺行性遗忘机制中的作用。结果发现，重复训练接受 D-环丝氨酸（一种 NMDA 受体甘氨酸部位的有效激动剂）治疗的健忘动物不会导致长期记忆的巩固，而与接受盐水预处理的对照动物相比，短期记忆的表达更为明显。结果表明，D-环丝氨酸在健忘蜗牛中不会影响在提示（不与无条件刺激结合）期间呈现条件刺激引起的食物反应。据假设，健忘动物的 NMDA 谷氨酸受体参与了短期记忆的神经可塑性机制，但它们的激活不会影响顺行性遗忘过程，也不会导致长期记忆的形成或恢复。
