类雪旺氏脂肪来源干细胞作为外周神经再生的一种有前景的治疗工具：胆碱能刺激的作用 - Suppr

Schwann-like adipose-derived stem cells as a promising therapeutic tool for peripheral nerve regeneration: effects of cholinergic stimulation.

作者信息

Piovesana Roberta, Faroni Alessandro, Tata Ada Maria, Reid Adam J

机构信息

Department of Biology and Biotechnologies "Charles Darwin", Sapienza, University of Rome, Rome, Italy; Blond McIndoe Laboratories, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.

Blond McIndoe Laboratories, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.

出版信息

Neural Regen Res. 2021 Jun;16(6):1218-1220. doi: 10.4103/1673-5374.300433.

DOI:10.4103/1673-5374.300433

PMID:33269784

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8224124/

Abstract

摘要

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Schwann-like adipose-derived stem cells as a promising therapeutic tool for peripheral nerve regeneration: effects of cholinergic stimulation.类雪旺氏脂肪来源干细胞作为外周神经再生的一种有前景的治疗工具：胆碱能刺激的作用

Neural Regen Res. 2021 Jun;16(6):1218-1220. doi: 10.4103/1673-5374.300433.

Adipose-Derived Stem Cells Promote Peripheral Nerve Regeneration In Vivo without Differentiation into Schwann-Like Lineage.脂肪来源干细胞在体内促进周围神经再生而不分化为雪旺氏样谱系。

Plast Reconstr Surg. 2016 Feb;137(2):318e-330e. doi: 10.1097/01.prs.0000475762.86580.36.

Cultures of Schwann-like cells differentiated from adipose-derived stem cells on PDMS/MWNT sheets as a scaffold for peripheral nerve regeneration.在聚二甲基硅氧烷/多壁碳纳米管片材上由脂肪来源干细胞分化而来的雪旺氏样细胞培养物作为周围神经再生的支架。

J Biomed Mater Res A. 2015 Nov;103(11):3642-8. doi: 10.1002/jbm.a.35488. Epub 2015 Jun 25.

The Combination of Adipose-derived Schwann-like Cells and Acellular Nerve Allografts Promotes Sciatic Nerve Regeneration and Repair through the JAK2/STAT3 Signaling Pathway in Rats.脂肪来源雪旺样细胞与去细胞神经同种异体移植物的联合通过 JAK2/STAT3 信号通路促进大鼠坐骨神经再生和修复。

Neuroscience. 2019 Dec 1;422:134-145. doi: 10.1016/j.neuroscience.2019.10.018. Epub 2019 Nov 1.

Undifferentiated and differentiated adipose-derived stem cells improve nerve regeneration in a rat model of facial nerve defect.未分化和分化的脂肪来源干细胞改善面神经缺损大鼠模型中的神经再生。

J Tissue Eng Regen Med. 2017 Feb;11(2):362-374. doi: 10.1002/term.1919. Epub 2014 Jun 1.

Schwann cell-like differentiated adipose stem cells promote neurite outgrowth via secreted exosomes and RNA transfer.许旺细胞样分化脂肪干细胞通过分泌的外泌体和 RNA 转移促进轴突生长。

Stem Cell Res Ther. 2018 Oct 11;9(1):266. doi: 10.1186/s13287-018-1017-8.

Differentiation of adipose-derived stem cells into Schwann cell-like cells through intermittent induction: potential advantage of cellular transient memory function.脂肪间充质干细胞通过间歇性诱导分化为施万样细胞：细胞瞬态记忆功能的潜在优势。

Stem Cell Res Ther. 2018 May 11;9(1):133. doi: 10.1186/s13287-018-0884-3.

Adipose-derived stem cells enhance peripheral nerve regeneration.脂肪来源干细胞促进周围神经再生。

J Plast Reconstr Aesthet Surg. 2010 Sep;63(9):1544-52. doi: 10.1016/j.bjps.2009.09.012. Epub 2009 Oct 13.

Practical considerations concerning the use of stem cells for peripheral nerve repair.关于使用干细胞进行周围神经修复的实际考量。

Neurosurg Focus. 2009 Feb;26(2):E2. doi: 10.3171/FOC.2009.26.2.E2.

Exosomes from human adipose-derived stem cells promote sciatic nerve regeneration via optimizing Schwann cell function.人脂肪间充质干细胞来源的外泌体通过优化施万细胞功能促进坐骨神经再生。

J Cell Physiol. 2019 Dec;234(12):23097-23110. doi: 10.1002/jcp.28873. Epub 2019 May 23.

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Acetylcholine muscarinic M2 receptor maintains human Schwann-like adipose-derived phenotype in the absence of differentiating medium.乙酰胆碱毒蕈碱M2受体在无分化培养基的情况下维持人雪旺氏样脂肪来源表型。

Cell Death Discov. 2025 Apr 13;11(1):170. doi: 10.1038/s41420-025-02404-0.

Perspectives on Schwann-like cells derived from bone marrow-mesenchymal stem cells: Advancing peripheral nerve injury therapies.源自骨髓间充质干细胞的类施万细胞的研究进展：推动周围神经损伤治疗

World J Stem Cells. 2025 Feb 26;17(2):102702. doi: 10.4252/wjsc.v17.i2.102702.

Histone Trimethylations and HDAC5 Regulate Spheroid Subpopulation and Differentiation Signaling of Human Adipose-Derived Stem Cells.组蛋白三甲基化和 HDAC5 调节人脂肪来源干细胞球体亚群和分化信号。

Stem Cells Transl Med. 2024 Mar 15;13(3):293-308. doi: 10.1093/stcltm/szad090.

Improving Schwann Cell Differentiation from Human Adipose Stem Cells with Metabolic Glycoengineering.通过代谢糖基工程提高人脂肪干细胞向雪旺细胞的分化。

Cells. 2023 Apr 19;12(8):1190. doi: 10.3390/cells12081190.

In Vitro Transdifferentiation Potential of Equine Mesenchymal Stem Cells into Schwann-Like Cells.马间充质干细胞向雪旺样细胞体外转分化潜能。

Stem Cells Dev. 2023 Jul;32(13-14):422-432. doi: 10.1089/scd.2022.0274. Epub 2023 Jun 7.

Emerging Roles of Cholinergic Receptors in Schwann Cell Development and Plasticity.胆碱能受体在施万细胞发育和可塑性中的新作用

Biomedicines. 2022 Dec 24;11(1):41. doi: 10.3390/biomedicines11010041.

Iron Metabolism and Ferroptosis in Peripheral Nerve Injury.铁代谢与周围神经损伤中的铁死亡。

Oxid Med Cell Longev. 2022 Dec 2;2022:5918218. doi: 10.1155/2022/5918218. eCollection 2022.

Membrane Progesterone Receptor α (mPRα/PAQR7) Promotes Survival and Neurite Outgrowth of Human Neuronal Cells by a Direct Action and Through Schwann Cell-like Stem Cells.膜孕激素受体 α（mPRα/PAQR7）通过直接作用和施万细胞样干细胞促进人神经元细胞的存活和突起生长。

J Mol Neurosci. 2022 Oct;72(10):2067-2080. doi: 10.1007/s12031-022-02057-z. Epub 2022 Aug 17.

Notch Signal Mediates the Cross-Interaction between M2 Muscarinic Acetylcholine Receptor and Neuregulin/ErbB Pathway: Effects on Schwann Cell Proliferation.Notch 信号介导 M2 毒蕈碱型乙酰胆碱受体与神经调节蛋白/表皮生长因子受体途径的交叉相互作用：对许旺细胞增殖的影响。

Biomolecules. 2022 Feb 1;12(2):239. doi: 10.3390/biom12020239.

本文引用的文献

Muscarinic receptors modulate Nerve Growth Factor production in rat Schwann-like adipose-derived stem cells and in Schwann cells.毒蕈碱受体调节大鼠类雪旺氏脂肪来源干细胞和雪旺氏细胞中神经生长因子的产生。

Sci Rep. 2020 Apr 28;10(1):7159. doi: 10.1038/s41598-020-63645-w.

M2 receptors activation modulates cell growth, migration and differentiation of rat Schwann-like adipose-derived stem cells.M2受体激活调节大鼠雪旺样脂肪来源干细胞的细胞生长、迁移和分化。

Cell Death Discov. 2019 May 3;5:92. doi: 10.1038/s41420-019-0174-6. eCollection 2019.

GABA-B1 Receptor-Null Schwann Cells Exhibit Compromised In Vitro Myelination.GABA-B1 受体缺失雪旺细胞表现出体外髓鞘形成受损。

Mol Neurobiol. 2019 Feb;56(2):1461-1474. doi: 10.1007/s12035-018-1158-x. Epub 2018 Jun 12.

M2 muscarinic receptor activation inhibits cell proliferation and migration of rat adipose-mesenchymal stem cells.M2 毒蕈碱型乙酰胆碱受体激活可抑制大鼠脂肪间充质干细胞的增殖和迁移。

J Cell Physiol. 2018 Jul;233(7):5348-5360. doi: 10.1002/jcp.26350. Epub 2018 Jan 23.

Human Schwann-like cells derived from adipose-derived mesenchymal stem cells rapidly de-differentiate in the absence of stimulating medium.源自脂肪间充质干细胞的人雪旺氏样细胞在缺乏刺激培养基的情况下会迅速去分化。

Eur J Neurosci. 2016 Feb;43(3):417-30. doi: 10.1111/ejn.13055. Epub 2015 Sep 18.

Peripheral nerve regeneration: experimental strategies and future perspectives.周围神经再生：实验策略与未来展望。

Adv Drug Deliv Rev. 2015 Mar;82-83:160-7. doi: 10.1016/j.addr.2014.11.010. Epub 2014 Nov 14.

M2 muscarinic receptor activation regulates Schwann cell differentiation and myelin organization.M2 毒蕈碱型乙酰胆碱受体激活调控施万细胞分化和髓鞘组织。

Dev Neurobiol. 2014 Jul;74(7):676-91. doi: 10.1002/dneu.22161. Epub 2014 Jan 9.

Differentiation of adipose-derived stem cells into Schwann cell phenotype induces expression of P2X receptors that control cell death.脂肪来源干细胞向施万细胞表型的分化诱导 P2X 受体的表达，从而控制细胞死亡。

Cell Death Dis. 2013 Jul 25;4(7):e743. doi: 10.1038/cddis.2013.268.

Glial differentiation of human adipose-derived stem cells: implications for cell-based transplantation therapy.人脂肪来源干细胞的神经胶质分化：对基于细胞的移植治疗的启示。

Neuroscience. 2013 Apr 16;236:55-65. doi: 10.1016/j.neuroscience.2012.12.066. Epub 2013 Jan 29.

Baclofen modulates the expression and release of neurotrophins in schwann-like adipose stem cells.巴氯芬调节许旺样脂肪干细胞中神经营养因子的表达和释放。

J Mol Neurosci. 2013 Feb;49(2):233-43. doi: 10.1007/s12031-012-9813-6. Epub 2012 May 31.

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Schwann-like adipose-derived stem cells as a promising therapeutic tool for peripheral nerve regeneration: effects of cholinergic stimulation.

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