Snell L D, Morter R S, Johnson K M
University of Texas Medical Branch, Department of Pharmacology and Toxicology, Galveston 77550.
Neurosci Lett. 1987 Dec 29;83(3):313-7. doi: 10.1016/0304-3940(87)90106-6.
In extensively washed preparations of rat cortical membranes, N-methyl-D-aspartate (NMDA) increases the specific binding of [3H]TCP by over 4-fold in a concentration dependent manner (EC50 = 3.1 microM). Glycine (1 microM) potentiates the maximal effect of NMDA by a factor of 1.7. The effect of glycine is concentration dependent (EC50 = 380 nM) and strychnine insensitive. These data are discussed with reference to the recently reported effects of glycine on the NMDA operated cation channel and the relationship between the PCP and NMDA receptors.
在经过充分洗涤的大鼠皮层膜制剂中，N-甲基-D-天冬氨酸（NMDA）以浓度依赖性方式（EC50 = 3.1微摩尔）使[3H]TCP的特异性结合增加超过4倍。甘氨酸（1微摩尔）使NMDA的最大效应增强1.7倍。甘氨酸的作用具有浓度依赖性（EC50 = 380纳摩尔）且对士的宁不敏感。结合最近报道的甘氨酸对NMDA操纵的阳离子通道的作用以及苯环己哌啶（PCP）与NMDA受体之间的关系对这些数据进行了讨论。
