Department of Orthopedic Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea (ROK).
Clinic of Oral Medicine and Orofacial Pain, Institute of Oral Health Science, Ajou University School of Medicine, Suwon, Gyeonggi-do, Korea (ROK).
PLoS One. 2020 Dec 3;15(12):e0243294. doi: 10.1371/journal.pone.0243294. eCollection 2020.
Mechanical and biochemical bone properties are influenced by muscles. However, the muscle-bone interaction has not been fully elucidated regarding the upper extremities. The objective of the present study was to evaluate the mechanical muscle-bone interaction at the forearm by evaluating the relationship between the properties of three-dimensional (3D) forearm cortical bone models derived from conventional computed tomography (CT) images and handgrip strength (HGS).
A total of 108 women (mean age, 75.2 ± 9.4 years; range, 62-101 years) with a distal radius fracture who took conventional CT scans for the assessment of the fracture were included in this study. Distal radius 3D models were reconstructed and the average cortical bone density (Cd) and thickness (Ct) of the region of interest (ROI), which might be affected by the forearm flexor muscles, were calculated using a 3D modeling software. Clinical parameters including HGS, lumbar and hip bone mineral densities (BMDs), and other demographic factors were also obtained. A multivariate linear regression analysis was performed to identify relevant factors associated with HGS.
HGS was found to be independently associated with height and Cd, but no significant difference was found between HGS and Ct, age, weight, as well as lumber and hip BMDs.
Cortical bone density might be associated with HGS, which is generated by the forearm flexor muscles. Hence, the mechanical muscle-bone interaction in the upper extremities could be supported by the present study.
肌肉会影响骨骼的力学和生化特性。然而，上肢的肌肉-骨骼相互作用尚未完全阐明。本研究的目的是通过评估源自常规计算机断层扫描（CT）图像的三维（3D）前臂皮质骨模型的特性与手握力（HGS）之间的关系，来评估前臂的力学肌肉-骨骼相互作用。
本研究共纳入 108 名女性（平均年龄 75.2±9.4 岁；年龄范围 62-101 岁），这些女性均因桡骨远端骨折接受了常规 CT 扫描以评估骨折情况。使用 3D 建模软件对桡骨远端 3D 模型进行重建，并计算感兴趣区域（ROI）的平均皮质骨密度（Cd）和厚度（Ct），这些区域可能受到前臂屈肌的影响。还获得了包括 HGS、腰椎和髋部骨密度（BMD）在内的临床参数以及其他人口统计学因素。进行了多元线性回归分析以确定与 HGS 相关的相关因素。
HGS 与身高和 Cd 独立相关，但 HGS 与 Ct、年龄、体重以及腰椎和髋部 BMD 之间无显著差异。
皮质骨密度可能与 HGS 相关，HGS 是由前臂屈肌产生的。因此，本研究可以支持上肢的力学肌肉-骨骼相互作用。
