NRG1 HapICE 基因变异对精神分裂症的指间距和皮纹测量的影响。
Impact of NRG1 HapICE gene variants on digit ratio and dermatoglyphic measures in schizophrenia.
机构信息
Translational Psychiatry Laboratory, Neurobiology Research Center, National Institute of Mental Health and Neurosciences, Bangalore, India; Department of Human Genetics, National Institute of Mental Health and Neurosciences, Bangalore, India.
Translational Psychiatry Laboratory, Neurobiology Research Center, National Institute of Mental Health and Neurosciences, Bangalore, India; InSTAR Program, Schizophrenia Clinic, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India.
出版信息
Asian J Psychiatr. 2020 Dec;54:102363. doi: 10.1016/j.ajp.2020.102363. Epub 2020 Aug 25.
Multiple lines of evidence have suggested a potential role of Neuregulin-1 (NRG1) in the neurodevelopmental pathogenesis of schizophrenia. Interaction between genetic risk variants present within NRG1 locus and non-specific gestational putative insults can significantly impair crucial processes of brain development. Such genetic effects can be analyzed through the assessment of digit ratio and dermatoglyphic patterns. We examined the role of two well-replicated polymorphisms of NRG1 (SNP8NRG221533 and SNP8NRG243177) on schizophrenia risk and its probable impact on the digit ratio and dermatoglyphic measures in patients (N = 221) and healthy controls (N = 200). In schizophrenia patients, but not in healthy controls, a significant association between NRG1 SNP8NRG221533 C/C genotype with lower left 2D:4D ratio, as well as with higher FA_TRC and DA_TRC. The substantial effect of SNP8NRG221533 on both digit ratio and dermatoglyphic measures suggest a potential role for NRG1 gene variants on neurodevelopmental pathogenesis of schizophrenia.
多项证据表明，神经调节蛋白-1（NRG1）在精神分裂症的神经发育发病机制中可能发挥作用。NRG1 基因座内存在的遗传风险变异与非特异性妊娠潜在损伤之间的相互作用，可显著损害大脑发育的关键过程。可以通过评估指比率和皮纹模式来分析这种遗传效应。我们研究了 NRG1 的两个经过充分验证的多态性（SNP8NRG221533 和 SNP8NRG243177）在精神分裂症风险中的作用及其对患者（N=221）和健康对照组（N=200）的指比率和皮纹测量值的可能影响。在精神分裂症患者中，但在健康对照组中，NRG1 SNP8NRG221533 C/C 基因型与较低的左手 2D:4D 比值以及较高的 FA_TRC 和 DA_TRC 之间存在显著关联。SNP8NRG221533 对指比率和皮纹测量值的显著影响表明，NRG1 基因变异可能在精神分裂症的神经发育发病机制中起作用。
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