Kumari Asha, Sharma Arun, Sharma Rahul, Malairaman Udayabanu, Raj Singh Ragini
Nanotechnology Laboratory, Department of Physics and Materials Science, Jaypee University of Information Technology, Waknaghat, Solan 173234, India; Department of Chemistry, Career Point University, Hamirpur 176041, India.
Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Waknaghat, Solan 173234, India.
Spectrochim Acta A Mol Biomol Spectrosc. 2021 Mar 5;248:119206. doi: 10.1016/j.saa.2020.119206. Epub 2020 Nov 16.
Proficient fluorescent-characteristics, cytotoxicity-behavior and antimicrobial-activity of near-infrared-emitting (NIR) CdTe quantum dots (QDs) were studied sumptuously as these QDs are having an excellence in deep-tissue dissemination of light. These, NIR-emitting QDs were synthesized using aqueous method, utilizing 3-mercaptopropionic-acid (3-MPA) as a stabilizer; it controls leakage of Cd and Te ions from CdTe QDs. However, encapsulation by polymers also prevents the same by seizing toxic consequence of prepared QDs which was confirmed from cytotoxicity studies. Therefore, easy modification according to biological environment of these encapsulated CdTe QDs can serve in bio imaging and distribution. Antimicrobial study investigated the toxic effects of QDs against bacterial strains and support cytotoxicity studies and showing maximum 26 mm zone of inhibition against bacterial strain. These, NIR fluorescent QDs possess many attractive optical properties over the standard fluorescent probes (organic dyes) and can replace these dyes, as there is no specific dye which works in NIR range.
对近红外发射（NIR）碲化镉量子点（QDs）的荧光特性、细胞毒性行为和抗菌活性进行了充分研究，因为这些量子点在光的深部组织传播方面表现出色。这些近红外发射量子点采用水相法合成，使用3-巯基丙酸（3-MPA）作为稳定剂；它可控制碲化镉量子点中镉和碲离子的泄漏。然而，聚合物包封也可通过消除所制备量子点的毒性后果来防止这种情况，这已从细胞毒性研究中得到证实。因此，根据这些包封的碲化镉量子点的生物环境进行简单修饰可用于生物成像和分布。抗菌研究考察了量子点对细菌菌株的毒性作用，并支持细胞毒性研究，结果显示对细菌菌株的最大抑菌圈为26毫米。这些近红外荧光量子点相对于标准荧光探针（有机染料）具有许多吸引人的光学特性，并且可以替代这些染料，因为没有在近红外范围内起作用的特定染料。
