Department of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, NH, 03756, United States.
Norris Cotton Cancer Center, The Geisel School of Medicine at Dartmouth, Lebanon, NH, 03756, United States.
Semin Immunol. 2020 Jun;49:101435. doi: 10.1016/j.smim.2020.101435. Epub 2020 Nov 30.
Long-lived memory CD8 T cells play important roles in tumor immunity. Studies over the past two decades have identified four subsets of memory CD8 T cells - central, effector, stem-like, and tissue resident memory - that either circulate through blood, lymphoid and peripheral organs, or reside in tissues where cancers develop. In this article, we will review studies from both pre-clinical mouse models and human patients to summarize the phenotype, distribution and unique features of each memory subset, and highlight specific roles of each subset in anti-tumor immunity. Moreover, we will discuss how stem-cell like and resident memory CD8 T cell subsets relate to exhausted tumor-infiltrating lymphocytes (TIL) populations. These studies reveal how memory CD8 T cell subsets together orchestrate durable immunity to cancer.
长寿记忆性 CD8 T 细胞在肿瘤免疫中发挥重要作用。过去二十年的研究已经确定了记忆性 CD8 T 细胞的四个亚群——中央型、效应型、干细胞样型和组织驻留型记忆性 CD8 T 细胞——它们要么循环于血液、淋巴和外周器官，要么驻留在癌症发生的组织中。在本文中，我们将回顾临床前小鼠模型和人类患者的研究，总结每个记忆亚群的表型、分布和独特特征，并强调每个亚群在抗肿瘤免疫中的特定作用。此外，我们将讨论干细胞样和驻留型记忆性 CD8 T 细胞亚群与耗竭的肿瘤浸润淋巴细胞 (TIL) 群体之间的关系。这些研究揭示了记忆性 CD8 T 细胞亚群如何共同协调对癌症的持久免疫力。
