Stubblefield E, Sanford J
Department of Genetics, University of Texas M.D. Anderson Hospital and Tumor Institute, Houston 77030.
Anticancer Res. 1987 Nov-Dec;7(6):1085-104.
As the molecular details of cancer have begun to unfold, it has become apparent that the cellular genetic apparatus is defective in the malignant cell. Accordingly, we have attempted to review the prominent aspects of genetics research as it impinges on the problem of cancer. Although the field is immense, we have tried to cover four major areas: human genetics, molecular genetics, somatic cell genetics, and developmental genetics. Oncogenes are considered in detail in all of these areas, and a new map (42 entries) of oncogene positions on human chromosomes is presented.
随着癌症分子细节逐渐被揭示，恶性细胞中的细胞遗传机制存在缺陷这一点已变得显而易见。因此，我们试图回顾遗传学研究的突出方面，因为它与癌症问题相关。尽管这个领域非常广阔，但我们试图涵盖四个主要领域：人类遗传学、分子遗传学、体细胞遗传学和发育遗传学。在所有这些领域中都详细讨论了癌基因，并给出了一张人类染色体上癌基因位置的新图谱（42个条目）。
