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冠心病预防面临的挑战 - 来自挪威一项长期随访研究的经验。

Challenges in coronary heart disease prevention - experiences from a long-term follow-up study in Norway.

机构信息

Department of Medicine, Drammen Hospital, Drammen, Norway.

Department of Behavioral Sciences in Medicine and Faculty of Medicine, University of Oslo, Oslo, Norway.

出版信息

Scand Cardiovasc J. 2021 Apr;55(2):73-81. doi: 10.1080/14017431.2020.1852308. Epub 2020 Dec 4.

Abstract

To determine longitudinal changes in lifestyle behaviour and lipid management in a chronic coronary heart disease (CHD) population. A multi-centre cohort study consecutively included 1127 patients at baseline in 2014-2015, on average 16 months after a CHD event. Data were collected from hospital records, a questionnaire and clinical examination. Seven hundred and seven of 1021 eligible patients participated in a questionnaire-based follow-up in 2019. Data were analysed with univariate statistics. After a mean follow-up of 4.7 years (SD 0.4) from baseline, the percentage of current smokers (15% versus 16%), obesity (23% versus 25%) and clinically significant symptoms of anxiety (21% versus 17%) and depression (13% versus 14%) remained unchanged, whereas the proportion with low physical activity increased from 53% to 58% ( < .001). The proportions with reduced physical activity level were similar in patients over and under 70 years of age. Most patients were still taking statins (94% versus 92%) and more patients used high-intensity statin (49% versus 54%,  < .001) and ezetimibe (5% versus 15%,  < .001) at follow-up. 73% reported ≥1 primary-care consultation(s) for CHD during the last year while 27% reported no such follow-up. There were more smokers among participants not attending primary-care consultations compared to those attending (19% versus 14%,  = .026). No differences were found for other risk factors. We found persistent suboptimal risk factor control in coronary outpatients during long-term follow-up. Closer follow-up and intensified risk management including lifestyle and psychological health are needed to improved secondary prevention and outcome of CHD. Registered at ClinicalTrials.gov: NCT02309255.Registered at 5 December 2014, registered retrospectively.

摘要

为了确定在慢性冠心病(CHD)人群中生活方式行为和血脂管理的纵向变化。一项多中心队列研究连续纳入了 2014-2015 年基线时的 1127 例患者,平均在 CHD 事件后 16 个月。数据来自医院记录、问卷和临床检查。1021 例符合条件的患者中有 707 例参加了 2019 年的基于问卷的随访。采用单变量统计分析数据。从基线开始平均随访 4.7 年(SD 0.4 年)后,当前吸烟者的比例(15%对 16%)、肥胖(23%对 25%)、临床显著焦虑症状(21%对 17%)和抑郁(13%对 14%)保持不变,而体力活动水平较低的比例从 53%增加到 58%( < .001)。70 岁以上和以下的患者减少体力活动的比例相似。大多数患者仍在服用他汀类药物(94%对 92%),更多患者在随访时使用高强度他汀类药物(49%对 54%, < .001)和依折麦布(5%对 15%, < .001)。73%的患者报告在过去一年中至少有 1 次因 CHD 就诊初级保健,而 27%的患者未进行此类随访。与参加者相比,未参加初级保健咨询的参与者中吸烟者比例更高(19%对 14%, = .026)。其他危险因素没有差异。我们发现,在长期随访中,冠心病门诊患者的危险因素控制仍然不理想。需要更密切的随访和强化风险管理,包括生活方式和心理健康,以改善 CHD 的二级预防和结局。在 ClinicalTrials.gov 注册:NCT02309255。于 2014 年 12 月 5 日注册,回顾性注册。

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