A shock-free approach for ambulatory cardioversion in atrial fibrillation.

Atrial fibrillation (AF), the most common persistent arrhythmia, is terminated most effectively by electrical cardioversion. This therapy requires in-hospital sedation to relieve the pain caused by electric shocks. Recently, our research group showed how the heart itself could be enabled to detect and terminate arrhythmias, including AF, thereby revealing the discovery of fully biological, shock-free cardioversion. Because of its biological nature, neither electric shocks nor hardware/software is required for sinus rhythm (SR) restoration, which creates a new perspective for ambulatory AF termination. Increasing evidence suggests that patients may indeed benefit from such continuous real-time rhythm control.