Department of Pediatrics, Member of the Diabetes Endocrine and Metabolism Pediatric Unit (DEMPU), Faculty of Medicine, Cairo University, Cairo, Egypt.
Department of Pediatrics, Faculty of Medicine, Diabetes, Endocrine and Metabolism Pediatric Unit (DEMPU), Children Hospital, Cairo University, Cairo, Egypt.
Diabetes Metab Syndr. 2021 Jan-Feb;15(1):7-12. doi: 10.1016/j.dsx.2020.11.020. Epub 2020 Nov 26.
To determine the effect of high protein and high fat meals on post prandial glycemia in patients with type 1 diabetes.
This study included 51 children and adolescents with type 1 diabetes who were following up at Diabetes, Endocrine and Metabolism Pediatric Unit (DEMPU), Abo Elrish Children's hospital, Cairo University. Post prandial blood glucose levels were recorded and compared following three breakfast meals with varying protein and fat content (standard carbohydrate meal, high fat meal, and high protein meal) over a period of 5 hours on 3 consecutive days.
High protein meal resulted in hyperglycemia with the peak level at 3.5 hours and continued for 5 hours post prandial while high fat meal caused early hyperglycemia reached the peak at 2 hours then declined towards 5 hours. Comparison of the three different breakfast meals revealed statistically significant difference regarding the postprandial glycemia at 30, 60, 90,120, 180, 210, 240, 270, 300 min.
Meals high in protein caused sustained increase in postprandial glucose levels over a period of 5 h. However, high fat meals caused early postprandial hyperglycemia. Protein and fat content of meals affect the timing and values of the peak blood glucose as well as the duration of postprandial hyperglycemia. Therefore, fat/protein unit should be taken in consideration while calculating the bolus insulin dose and anticipating the postprandial glucose response.
旨在确定高蛋白和高脂肪餐对 1 型糖尿病患者餐后血糖的影响。
本研究纳入了在开罗大学 Abo Elrish 儿童医院糖尿病、内分泌和代谢儿科病房（DEMPU）接受随访的 51 名 1 型糖尿病儿童和青少年。在连续 3 天的 5 小时内，记录并比较了三种不同早餐的餐后血糖水平，这三种早餐的蛋白质和脂肪含量不同（标准碳水化合物餐、高脂肪餐和高蛋白餐）。
高蛋白餐导致高血糖，峰值出现在 3.5 小时，餐后 5 小时仍持续升高，而高脂肪餐导致早期高血糖，峰值出现在 2 小时，然后在 5 小时内下降。三种不同早餐的比较显示，餐后血糖在 30、60、90、120、180、210、240、270、300 分钟时存在统计学差异。
高蛋白餐在 5 小时内持续升高餐后血糖水平。然而，高脂肪餐会导致餐后早期高血糖。膳食中的蛋白质和脂肪含量会影响餐后血糖峰值的时间和数值以及餐后高血糖的持续时间。因此，在计算餐时胰岛素剂量和预测餐后血糖反应时，应考虑脂肪/蛋白质单位。
