多发性骨髓瘤首次诊断时的疫苗接种：法国国家健康保险数据库队列研究
Vaccination during the First Diagnosis of Multiple Myeloma: A Cohort Study of the French National Health Insurance Database.
作者信息
Tournaire Guilhem, Conte Cécile, Perrot Aurore, Lapeyre-Mester Maryse, Despas Fabien
机构信息
Service de Pharmacologie Médicale et Clinique, CHU de Toulouse, 31000 Toulouse, France.
UMR1027, Inserm, Université Paul Sabatier, 31330 Toulouse, France.
出版信息
Vaccines (Basel). 2020 Dec 2;8(4):722. doi: 10.3390/vaccines8040722.
PURPOSE
Infections are frequent and often result in serious complications in patients with multiple myeloma (MM). Prophylactic vaccination is recommended for influenza virus, , and . The aims of this study were to measure the vaccination rates within 24 months after the diagnosis of multiple myeloma and to identify factors associated with vaccine use.
METHODS
MM patients were selected through the French national health insurance database from 1 January 2010 to 31 December 2015. Patients with a previous history of MM were excluded.
RESULTS
Vaccination rates against influenza, and among 22,831 newly diagnosed MM patients were, respectively, 28.5%, 10.3%, and 1.4%. Only 0.7% received all three vaccines. Factors associated with vaccination were young age, male gender, an absence of comorbidity, a history of higher medication and vaccine consumption, Herpes simplex virus (HSV), Varicella zoster virus (VZV), and the use of pneumocystis prophylaxis.
CONCLUSION
The low rates of vaccination indicate the need to improve physician and MM patient adherence and education regarding vaccination.
目的
感染在多发性骨髓瘤（MM）患者中很常见，且常常导致严重并发症。推荐对流感病毒、[此处原文缺失两种疫苗名称]进行预防性接种。本研究的目的是测量多发性骨髓瘤诊断后24个月内的疫苗接种率，并确定与疫苗使用相关的因素。
方法
通过法国国家健康保险数据库选取2010年1月1日至2015年12月31日期间的MM患者。排除既往有MM病史的患者。
结果
22,831例新诊断的MM患者中，流感、[此处原文缺失两种疫苗名称]疫苗接种率分别为28.5%、10.3%和1.4%。仅0.7%的患者接种了全部三种疫苗。与疫苗接种相关的因素包括年轻、男性、无合并症、有较高的用药和疫苗使用史、单纯疱疹病毒（HSV）、水痘带状疱疹病毒（VZV）以及使用肺孢子菌预防用药。
结论
疫苗接种率低表明需要提高医生和MM患者对疫苗接种的依从性并加强相关教育。
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