Wilson N M, Green S, Coe C, Barnes P J
Department of Paediatrics and Neonatal Medicine, Hammersmith Hospital, London, UK.
Eur J Respir Dis. 1987 Nov;71(5):455-8.
In order to determine the duration of action of the inhaled anticholinergic agent oxitropium bromide, a controlled study of the effect of pre-treatment with oxitropium bromide 200 micrograms against cholinergic challenge was carried out in ten asthmatic subjects (6 children, 4 adults). After baseline measurements of lung function (FEV1 and sGaw) and methacholine PC20 (the concentration of methacholine to produce a 20% fall in FEV1) oxitropium bromide or placebo were inhaled double-blind on 2 separate days. Lung function and methacholine PC20 were then measured at 1, 3 and 6 h post dosing. Oxitropium bromide caused significant protection from methacholine challenge for 6 h (p less than 0.05).
为了确定吸入性抗胆碱能药物氧托溴铵的作用持续时间，在10名哮喘患者（6名儿童，4名成人）中进行了一项对照研究，比较200微克氧托溴铵预处理对胆碱能激发试验的影响。在对肺功能（第一秒用力呼气容积[FEV1]和比气道传导率[sGaw]）以及乙酰甲胆碱激发试验浓度（使FEV1下降20%的乙酰甲胆碱浓度）进行基线测量后，在2个不同日期双盲吸入氧托溴铵或安慰剂。然后在给药后1、3和6小时测量肺功能和乙酰甲胆碱激发试验浓度。氧托溴铵在6小时内对乙酰甲胆碱激发试验有显著的保护作用（p<0.05）。
