肿瘤浸润自然杀伤细胞。
Tumor-Infiltrating Natural Killer Cells.
机构信息
Innate Pharma Research Laboratories, Innate Pharma, Marseille, France.
Center of Excellence for Biomedical Research, University of Genoa, Genoa, Italy.
出版信息
Cancer Discov. 2021 Jan;11(1):34-44. doi: 10.1158/2159-8290.CD-20-0655. Epub 2020 Dec 4.
Abstract
Because of their potent antitumor activity and their proinflammatory role, natural killer (NK) cells are at the forefront of efforts to develop immuno-oncologic treatments. NK cells participate in immune responses to tumors by killing target cells and producing cytokines. However, in the immunosuppressive tumor microenvironment, NK cells become dysfunctional through exposure to inhibitory molecules produced by cancer cells, leading to tumor escape. We provide an overview of what is known about NK tumor infiltration and surveillance and about the mechanisms by which NK cells become dysfunctional. SIGNIFICANCE: The functions of tumor-infiltrating NK cells may be impaired. This review aims to describe the various mechanisms by which tumors alter NK-cell functions.
摘要
由于其强大的抗肿瘤活性和促炎作用，自然杀伤 (NK) 细胞成为免疫肿瘤治疗发展的前沿。NK 细胞通过杀死靶细胞和产生细胞因子参与肿瘤的免疫反应。然而，在免疫抑制的肿瘤微环境中，NK 细胞通过暴露于癌细胞产生的抑制分子而功能失调，导致肿瘤逃逸。我们概述了 NK 细胞浸润和监测肿瘤以及 NK 细胞功能失调的机制。意义：肿瘤浸润 NK 细胞的功能可能受损。本综述旨在描述肿瘤改变 NK 细胞功能的各种机制。
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