Department of Pathology and Lab Medicine, All India Institute of Medical Sciences, Jodhpur, India.
Department of Diagnostic and Interventional Radiology, All India Institute of Medical Sciences, Jodhpur, India.
Diagn Cytopathol. 2021 Jun;49(6):E218-E221. doi: 10.1002/dc.24679. Epub 2020 Dec 5.
Histiocytic sarcoma is an extremely rare malignant hematological histiocytic neoplasm which is a diagnosis of exclusion based on its morphological and predominantly immunohistochemical criteria.
A 63-year female presented with complaints of a midline neck swelling along with right sided neck swelling. On fine-needle aspiration (FNA) from the thyroid lesion and the right cervical lymph node, the smears showed similar findings and a provisional morphological diagnosis of malignant spindle cell neoplasm was kept. On immunohistochemistry, the tumor cells showed immunoreactivity for vimentin, CD45, CD 68 and fascin and were immunonegative for thyroglobulin, S100, CD21, CD3, CD4 and other markers. Based on the immunohistochemical profile, a diagnosis of histiocytic sarcoma was established.
Histiocytic sarcoma is a rare malignant neoplasm that can be easily missed in thyroid resembling an anaplastic carcinoma.
组织细胞肉瘤是一种极其罕见的恶性血液组织细胞肿瘤，其诊断基于形态学和主要免疫组织化学标准，需要排除其他诊断。
一名 63 岁女性因颈中线肿胀和右侧颈部肿胀就诊。甲状腺病变和右侧颈部淋巴结的细针抽吸（FNA）涂片显示相似的发现，临时形态学诊断为恶性梭形细胞肿瘤。免疫组织化学显示肿瘤细胞表达波形蛋白、CD45、CD68 和 fascin，免疫阴性反应包括甲状腺球蛋白、S100、CD21、CD3、CD4 和其他标志物。根据免疫组织化学特征，诊断为组织细胞肉瘤。
组织细胞肉瘤是一种罕见的恶性肿瘤，在类似于间变性癌的甲状腺中容易被漏诊。
