中晚期早产儿促甲状腺激素参考范围。
Thyroid-stimulating hormone reference ranges for moderate-to-late preterm infants.
机构信息
Department of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA.
Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, USA.
出版信息
J Perinatol. 2021 Nov;41(11):2664-2667. doi: 10.1038/s41372-020-00895-6. Epub 2020 Dec 5.
BACKGROUND
Identifying congenital hypothyroidism through newborn screening (NBS) is higher among moderate-to-late preterm (MLPT) infants. Currently, the same thyroid-stimulating hormone (TSH) cutoffs are used for term and preterm infants. TSH reference ranges for MLPT infants are not currently available.
OBJECTIVE
To determine TSH reference ranges for MLPT infants.
METHODS
We analyzed 10,987 TSH levels on NBS samples performed on 8499 MLPT infants born between 32 and 36 weeks gestation.
RESULTS
TSH median, 5th, 25th, 75th, 95th, and 99th percentiles were defined from day 1 until day 14 of life. TSH levels gradually decreased after birth and reached a plateau around day 6.
CONCLUSION
Using a state-wide cohort, we constructed TSH reference charts from day 1 until day 14 for MLPT infants. Relationship between age-adjusted TSH percentiles and long-term neurodevelopmental outcomes should be determined in future studies to define optimal TSH cutoffs for MLPT infants.
背景
通过新生儿筛查（NBS）发现的先天性甲状腺功能减退症在中晚期早产儿（MLPT）中更为常见。目前，用于足月和早产儿的促甲状腺激素（TSH）切点相同。目前还没有 MLPT 婴儿的 TSH 参考范围。
目的
确定 MLPT 婴儿的 TSH 参考范围。
方法
我们分析了在 32 至 36 周胎龄出生的 8499 名 MLPT 婴儿的 NBS 样本中进行的 10987 个 TSH 水平。
结果
定义了从第 1 天到第 14 天的 TSH 中位数、第 5 百分位、第 25 百分位、第 75 百分位、第 95 百分位和第 99 百分位。出生后 TSH 水平逐渐下降，并在第 6 天左右达到平台期。
结论
我们使用全州范围的队列，为 MLPT 婴儿建立了从第 1 天到第 14 天的 TSH 参考图表。未来的研究应确定校正年龄后的 TSH 百分位数与长期神经发育结局之间的关系，以确定 MLPT 婴儿的最佳 TSH 切点。
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