Centre de Recherches en Cancérologie de Toulouse UMR 1037, Toulouse, France; INSERM UMR 1037 Université Toulouse III Paul Sabatier, Toulouse, France.
Joint Department of Physics, The Royal Marsden NHS Foundation Trust and Institute of Cancer Research, Sutton, Surrey, UK.
Clin Oncol (R Coll Radiol). 2021 Feb;33(2):117-124. doi: 10.1016/j.clon.2020.11.005. Epub 2020 Dec 3.
Molecular radiotherapy is a rapidly developing field with new vector and isotope combinations continually added to market. As with any radiotherapy treatment, it is vital that the absorbed dose and toxicity profile are adequately characterised. Methodologies for absorbed dose calculations for radiopharmaceuticals were generally developed to characterise stochastic effects and not suited to calculations on a patient-specific basis. There has been substantial scientific and technological development within the field of molecular radiotherapy dosimetry to answer this challenge. The development of imaging systems and advanced processing techniques enable the acquisition of accurate measurements of radioactivity within the body. Activity assessment combined with dosimetric models and radiation transport algorithms make individualised absorbed dose calculations not only feasible, but commonplace in a variety of commercially available software packages. The development of dosimetric parameters beyond the absorbed dose has also allowed the possibility to characterise the effect of irradiation by including biological parameters that account for radiation absorbed dose rates, gradients and spatial and temporal energy distribution heterogeneities. Molecular radiotherapy is in an exciting time of its development and the application of dosimetry in this field can only have a positive influence on its continued progression.
分子放射治疗是一个快速发展的领域，新的载体和同位素组合不断推向市场。与任何放射治疗一样，充分描述吸收剂量和毒性特征至关重要。放射性药物吸收剂量计算的方法通常是为了描述随机效应而开发的，不适合基于患者的具体情况进行计算。在分子放射治疗剂量学领域已经取得了大量的科学和技术进展，以应对这一挑战。成像系统和先进处理技术的发展使人们能够在体内准确测量放射性。活性评估与剂量模型和辐射传输算法相结合，使得个体化吸收剂量计算不仅可行，而且在各种商业上可用的软件包中也很常见。除了吸收剂量之外，还开发了剂量学参数，从而有可能通过包括辐射吸收剂量率、梯度以及空间和时间能量分布异质性的生物学参数来描述照射的效果。分子放射治疗正处于发展的激动人心的时期，在该领域应用剂量学只能对其持续发展产生积极影响。
