细胞-细胞接触引导固有免疫中的细胞迁移。
Cell Migration Guided by Cell-Cell Contacts in Innate Immunity.
机构信息
Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, USA.
Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, USA; Molecular and Cellular Pharmacology Graduate Training Program, University of Wisconsin-Madison, Madison, WI, USA.
出版信息
Trends Cell Biol. 2021 Feb;31(2):86-94. doi: 10.1016/j.tcb.2020.11.002. Epub 2020 Dec 3.
Abstract
The directed migration of leukocytes to sites of damage or infection is necessary for a productive immune response. There is substantial evidence supporting a key role for chemoattractants in directed migration, however, less is known about how cell-cell contacts affect the migratory behavior of leukocytes in innate immunity. Here, we explore how cell-cell contacts can affect the directed migration of innate immune cells, including their role in attracting, repelling, or stopping cell motility. Further investigation of cell contact dynamics as guidance cues may yield new insights into the regulation of innate immunity.
摘要
白细胞定向迁移到损伤或感染部位对于产生有效的免疫反应是必要的。有大量证据支持趋化因子在定向迁移中的关键作用，然而，对于细胞-细胞接触如何影响先天免疫中白细胞的迁移行为知之甚少。在这里，我们探讨了细胞-细胞接触如何影响先天免疫细胞的定向迁移，包括它们在吸引、排斥或阻止细胞运动方面的作用。进一步研究细胞接触动力学作为导向线索可能为先天免疫的调节提供新的见解。
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