Li Xiaoshuai, Zhao Pengfei, Qiu Xiaoyu, Ding Heyu, Lv Han, Yang Zhenghan, Gong Shusheng, Wang Zhenchang
Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Front Hum Neurosci. 2020 Nov 17;14:591260. doi: 10.3389/fnhum.2020.591260. eCollection 2020.
To investigate cerebral blood flow (CBF) differences in patients with left- and right-sided pulsatile tinnitus (LPT and RPT) and healthy controls (HCs) to further explore the lateralization effects of PT using arterial spin labeling (ASL). ASL data from 21 RPT patients, 17 LPT patients and 21 HCs were reviewed. Voxel-wise analysis and region of interest analysis were performed to explore differences in CBF among the three groups. Tinnitus Handicap Inventory (THI) score and tinnitus duration were obtained from each patient. Voxel-wise analysis showed that the CBF of the left inferior parietal gyrus was increased in both RPT and LPT patients compared with HCs ( < 0.001). Region of interest analysis revealed that the CBF of the left primary auditory cortex (PAC) was higher than that of the right, while the CBF of the right secondary auditory cortex (SAC) and auditory association cortex was higher than that of the left. These lateralization effects were present in all three groups. Compared with HCs, RPT patients showed increased CBF in the left PAC and SAC (PAC: = 0.036; SAC: = 0.012). No significant correlations were found between PT duration or THI score and altered CBF in above regions. Increased CBF in the left inferior parietal gyrus is a common feature in both RPT and LPT patients, regardless of the perceived side of PT. The lateralization effects of auditory cortices may be a physiological characteristic of the normal brain. These findings may provide a new perspective for understanding the neurological pathophysiology of PT.
为了研究左侧和右侧搏动性耳鸣（LPT和RPT）患者与健康对照者（HCs）的脑血流量（CBF）差异，以使用动脉自旋标记（ASL）进一步探索搏动性耳鸣的侧化效应。回顾了21例RPT患者、17例LPT患者和21例HCs的ASL数据。进行了体素分析和感兴趣区域分析，以探讨三组之间CBF的差异。从每位患者获得耳鸣障碍量表（THI）评分和耳鸣持续时间。体素分析显示，与HCs相比，RPT和LPT患者左侧顶下小叶的CBF均增加（<0.001）。感兴趣区域分析显示，左侧初级听觉皮层（PAC）的CBF高于右侧，而右侧次级听觉皮层（SAC）和听觉联合皮层的CBF高于左侧。所有三组均存在这些侧化效应。与HCs相比，RPT患者左侧PAC和SAC的CBF增加（PAC： =0.036；SAC： =0.012）。在上述区域，未发现PT持续时间或THI评分与CBF改变之间存在显著相关性。无论感知到的PT侧如何，左侧顶下小叶CBF增加是RPT和LPT患者的共同特征。听觉皮层的侧化效应可能是正常大脑的生理特征。这些发现可能为理解PT的神经病理生理学提供新的视角。
