Department of Urology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Front Endocrinol (Lausanne). 2020 Nov 13;11:586909. doi: 10.3389/fendo.2020.586909. eCollection 2020.
Androgens are some of the most important sex hormones in men, and they maintain important physiological activities in the human body. Cognitive impairment is one of the most common manifestations of aging in the elderly population and an important factor affecting the quality of life of elderly individuals. The levels of sex hormones in elderly people decrease with age, and low levels of androgens in older male individuals have been closely linked to the development of cognitive impairment. Basic studies have shown that androgens have neuroprotective effects and that androgen deficiency impairs cognitive function by increasing oxidative stress and decreasing synaptic plasticity, among other effects. Additionally, clinical studies have also shown that androgen deficiency is closely related to cognitive impairment. This article reviews the relationship between low androgen levels and cognitive impairment, their potential mechanisms, and the effects of testosterone supplementation in improving cognition.
雄激素是男性最重要的性激素之一，它们维持着人体的重要生理活动。认知障碍是老年人群体中最常见的衰老表现之一，也是影响老年个体生活质量的重要因素。老年人的性激素水平随年龄增长而下降，老年男性雄激素水平低与认知障碍的发展密切相关。基础研究表明，雄激素具有神经保护作用，雄激素缺乏通过增加氧化应激和减少突触可塑性等作用损害认知功能。此外，临床研究还表明，雄激素缺乏与认知障碍密切相关。本文综述了低雄激素水平与认知障碍的关系、它们的潜在机制以及睾酮补充改善认知的作用。
