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在医科达Unity MR直线加速器中进行脊柱立体定向体部放射治疗的可行性。

Feasibility of spinal stereotactic body radiotherapy in Elekta Unity MR-Linac.

作者信息

Han Eun Young, Aima Manik, Hughes Neil, Briere Tina M, Yeboa Debra N, Castillo Pam, Wang Jihong, Yang Jinzhong, Vedam Sastry

机构信息

Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

出版信息

J Radiosurg SBRT. 2020;7(2):127-134.

Abstract

The Elekta Unity MR-Linac (MRL) is expected to benefit spine stereotactic body radiotherapy (SBRT) due to the improved soft tissue contrast available with onboard MR imaging. However, the irradiation geometry and beam configuration of the MRL deviates from the conventional linear accelerator (Linac). The purpose of the study was to investigate the feasibility of spine SBRT on the MRL. Treatment plans were generated for lumbar and thoracic spines. Target and spinal cord doses were measured with two cylindrical ion chambers inserted into an anthropomorphic spine phantom. Our study indicated that the Monaco treatment planning system (TPS) could generate clinical treatment plans for the MRL that were of comparable quality to the RayStation TPS with a conventional Linac. For both Linacs the planned dose within the gross tumor volume agreed with measurements within ±3%. For the spinal cord, while the measured doses from the TrueBeam were 1.8% higher for the lumbar spine plan and 6.9% higher for thoracic spine plan, the measured doses from MRL were 0.6% lower for the lumbar spine plan and 3.9% higher for the thoracic spine plan. In conclusion, the feasibility of spine SBRT in Elekta Unity MRL has been demonstrated, however, more effort is needed for such as optimizing the online plan adaptation method.

摘要

由于机载磁共振成像(MR)可提供更好的软组织对比度,医科达Unity磁共振直线加速器(MR-Linac)有望在脊柱立体定向体部放疗(SBRT)中发挥作用。然而,MR-Linac 的照射几何形状和射束配置与传统直线加速器(Linac)不同。本研究的目的是探讨在 MR-Linac 上进行脊柱 SBRT 的可行性。针对腰椎和胸椎生成了治疗计划。将两个圆柱形电离室插入人体脊柱模型中,测量靶区和脊髓的剂量。我们的研究表明,Monaco 治疗计划系统(TPS)可为 MR-Linac 生成与配备传统 Linac 的 RayStation TPS 质量相当的临床治疗计划。对于两种 Linac,大体肿瘤体积内的计划剂量与测量值的偏差在±3%以内。对于脊髓,虽然 TrueBeam 的腰椎计划测量剂量高 1.8%,胸椎计划测量剂量高 6.9%,但 MR-Linac 的腰椎计划测量剂量低 0.6%,胸椎计划测量剂量高 3.9%。总之,已证明在医科达Unity MR-Linac 上进行脊柱 SBRT 的可行性,然而,在优化在线计划适配方法等方面仍需付出更多努力。

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