Tian Min, Qi Yingao, Zhang Xiaoli, Wu Zhihui, Chen Jiaming, Chen Fang, Guan Wutai, Zhang Shihai
Guangdong Province Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, China.
College of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, China.
Front Cell Dev Biol. 2020 Nov 17;8:604896. doi: 10.3389/fcell.2020.604896. eCollection 2020.
Janus kinase 2 (JAK2) and signal transducers and activators of transcription 5 (STAT5) are involved in the proliferation, differentiation, and survival of mammary gland epithelial cells. Dysregulation of JAK2-STAT5 activity invariably leads to mammary gland developmental defects and/or diseases, including breast cancer. Proper functioning of the JAK2-STAT5 signaling pathway relies on crosstalk with other signaling pathways (synergistically or antagonistically), which leads to normal biological performance. This review highlights recent progress regarding the critical components of the JAK2-STAT5 pathway and its crosstalk with G-protein coupled receptor (GPCR) signaling, PI3K-Akt signaling, growth factors, inflammatory cytokines, hormone receptors, and cell adhesion.
Janus激酶2（JAK2）和信号转导及转录激活因子5（STAT5）参与乳腺上皮细胞的增殖、分化和存活。JAK2-STAT5活性失调总是导致乳腺发育缺陷和/或疾病，包括乳腺癌。JAK2-STAT5信号通路的正常功能依赖于与其他信号通路的相互作用（协同或拮抗），从而导致正常的生物学表现。本综述重点介绍了JAK2-STAT5通路关键成分及其与G蛋白偶联受体（GPCR）信号、PI3K-Akt信号、生长因子、炎性细胞因子、激素受体和细胞黏附相互作用的最新进展。
