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一只10岁杰克罗素梗犬的慢性淋巴细胞浆细胞性绒毛结节性增生性滑膜炎。

Chronic lymphoplasmacytic villonodular proliferative synovitis in a 10-year-old Jack Russell Terrier dog.

作者信息

Mapuvire Tafara, Kandiwa Erick, Mbiri Pricilla, Samkange Alaster, Madzingira Oscar, Mushonga Borden

机构信息

Surgivet Veterinary Consultancy, Johannesburg, South Africa.

Biomedical Sciences Department, School of Veterinary Medicine, Faculty of Agriculture and Natural Resources, Neudamm Campus, University of Namibia, Windhoek, Namibia.

出版信息

Int J Vet Sci Med. 2020 Nov 18;8(1):100-105. doi: 10.1080/23144599.2020.1842038.

DOI:10.1080/23144599.2020.1842038
PMID:33282937
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7682736/
Abstract

We describe a case of chronic lymphoplasmacytic villonodular synovitis (CLPVNS) associated with cranial cruciate ligament (CCL) disease in a 10-year-old spayed Jack Russell Terrier bitch. The bitch was presented to a veterinary clinic with severe, non-weight bearing, acute left hindlimb lameness. The bitch had previously been treated surgically for stifle CCL disease of the same joint, using the lateral fabellar suture (LFS) technique. Since the treatment, the patient had a history of intermittent left hindlimb non-weight bearing lameness that was manageable with nonsteroidal anti-inflammatory drugs (NSAIDs). Palpation and manipulation of the affected stifle elicited severe pain. There were no other clinical or orthopaedic abnormalities. Orthogonal radiographs of the affected stifle revealed moderate degenerative joint disease and osteolytic lesions on the lateral aspect of the lateral femoral condyle and the head of the fibula. A fluid aspirate from this joint was negative for bacterial growth on culture. Cytology results were suspicious for CLPVNS. Exploratory arthrotomy, synovectomy, debridement and lavage of the affected joint were performed. Bone and synovial membrane biopsy samples of the joint were obtained and submitted to a laboratory for a histopathological confirmatory diagnosis. CLPVNS was tentatively diagnosed by cytology, and confirmed by histopathology of biopsy samples. This case report highlights the importance of checking for CLPVNS in dogs with lameness associated with CCL disease, as reports show it to be underreported or misdiagnosed.

摘要

我们描述了一例10岁绝育的杰克罗素梗犬母犬,患有与颅交叉韧带(CCL)疾病相关的慢性淋巴细胞浆细胞性绒毛结节性滑膜炎(CLPVNS)。这只母犬因严重的、非负重性急性左后肢跛行被送至一家兽医诊所。这只母犬此前曾因同一关节的膝关节CCL疾病接受过手术治疗,采用的是外侧腓骨缝合(LFS)技术。自治疗后,该患者有间歇性左后肢非负重性跛行病史,使用非甾体抗炎药(NSAIDs)可控制。触诊和操作患侧膝关节会引起剧痛。没有其他临床或骨科异常。患侧膝关节的正位X线片显示中度退行性关节病以及股骨外侧髁外侧和腓骨头处的溶骨性病变。从该关节抽取的液体培养结果显示细菌生长为阴性。细胞学检查结果怀疑为CLPVNS。对患侧关节进行了探查性关节切开术、滑膜切除术、清创术和灌洗术。获取了该关节的骨和滑膜活检样本并送至实验室进行组织病理学确诊。通过细胞学初步诊断为CLPVNS,并经活检样本的组织病理学确诊。本病例报告强调了在患有与CCL疾病相关跛行的犬中检查CLPVNS的重要性,因为报告显示该病报告不足或误诊。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8794/7682736/29de9b8e847b/TVSM_A_1842038_F0003_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8794/7682736/d30ee71329a1/TVSM_A_1842038_F0001_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8794/7682736/0af5f4bdbd09/TVSM_A_1842038_F0002_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8794/7682736/29de9b8e847b/TVSM_A_1842038_F0003_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8794/7682736/d30ee71329a1/TVSM_A_1842038_F0001_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8794/7682736/0af5f4bdbd09/TVSM_A_1842038_F0002_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8794/7682736/29de9b8e847b/TVSM_A_1842038_F0003_B.jpg

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本文引用的文献

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恶性腱鞘巨细胞瘤:真正的“滑膜肉瘤”?10 例临床病理、免疫组化和分子细胞遗传学研究,支持源自滑膜细胞。
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