Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Breast Surgery, True Family Women's Cancer Center, Seattle, WA, USA.
Breast J. 2020 Dec;26(12):2391-2394. doi: 10.1111/tbj.14093. Epub 2020 Dec 6.
Intraoperative radiation therapy (IORT) has been shown to reduce local recurrence rates among women with early-stage invasive ductal carcinoma, but data regarding its use among women with in situ carcinoma are limited. In this single-institution study, 50 women with in situ carcinoma were treated with oncoplastic breast-conserving surgery (OPS) and single-dose IORT. All 50 patients had "no tumor on ink," but 9 (16%) had margins < 2 mm and required additional therapy. No local recurrences were observed after a median follow-up of 46 months. Single-dose IORT is an efficacious treatment for well-selected patients with DCIS.
术中放疗（IORT）已被证明可降低早期浸润性导管癌女性的局部复发率，但有关其在原位癌女性中应用的数据有限。在这项单机构研究中，50 例原位癌患者接受了保乳整形手术（OPS）和单次剂量 IORT 治疗。所有 50 例患者均为“墨水上无肿瘤”，但有 9 例（16%）切缘<2mm，需要额外治疗。中位随访 46 个月后，未观察到局部复发。单次剂量 IORT 是一种有效的治疗方法，适用于选择良好的 DCIS 患者。
