Abdulkadir J, Mengesha B, Gebriel Z W, Gebre P, Beastall G, Thompson J A
Department of Internal Medicine, Faculty of Medicine, Addis Ababa University, Ababa, Ethiopia.
Trans R Soc Trop Med Hyg. 1987;81(4):539-43. doi: 10.1016/0035-9203(87)90398-1.
Anthropometric, clinical and biochemical findings were compared in 30 rural (group A), 18 urban insulin-requiring (group B) and 45 urban oral-agent-responsive (group C) newly diagnosed diabetics. Mean ages at onset were 28.3 +/- 12.0, 25.6 +/- 14.5 and 42.1 +/- 10.5 years respectively. The differences between A and C and between B and C were significant. Group A were poor and malnourished, with body mass index (BMI) 15.9 +/- 1.9 and 17.2 +/- 3.7 kg/m2 for males and females respectively, presented with a long history of classical diabetes without ketoacidosis and required insulin in modest doses. 3 of 10 cases had excess stool fat but none of 13 unselected cases had pancreatic calcification. Group C were better nourished, with BMI 22.6 +/- 2.8 and 22.4 +/- 4.5 kg/m2, and responded to oral agents. Group B, with BMI 17.2 +/- 2.6 and 18.6 +/- 3.1 kg/m2, required insulin for control but had C-peptide levels above 0.02 nmol/1 in 10 of 15 cases. Anthropometric indices for males, but not for females, were significantly lower in group A than in group B or C. There were significant differences in levels of glucose between A and B and A and C, free fatty acids between A and C and B and C, insulin between A and B and A and C and C-peptide between A and C and B and C. Of the 3 groups the rural type most closely resembled the tropical variants.
对30例新诊断的农村糖尿病患者（A组）、18例城市需用胰岛素治疗的糖尿病患者（B组）和45例城市口服降糖药有效的糖尿病患者（C组）的人体测量学、临床和生化指标进行了比较。发病时的平均年龄分别为28.3±12.0岁、25.6±14.5岁和42.1±10.5岁。A组与C组之间以及B组与C组之间的差异具有显著性。A组患者贫困且营养不良，男性和女性的体重指数（BMI）分别为15.9±1.9和17.2±3.7kg/m²，有长期典型糖尿病病史且无酮症酸中毒，需用小剂量胰岛素治疗。10例患者中有3例粪便脂肪过多，但13例未选病例中均无胰腺钙化。C组营养状况较好，BMI为22.6±2.8和22.4±4.5kg/m²，对口服降糖药有反应。B组BMI为17.2±2.6和18.6±3.1kg/m²，需用胰岛素控制血糖，但15例中有10例C肽水平高于0.02nmol/1。A组男性的人体测量指数显著低于B组或C组，但女性并非如此。A组与B组、A组与C组之间的血糖水平、A组与C组、B组与C组之间的游离脂肪酸水平、A组与B组、A组与C组之间的胰岛素水平以及A组与C组、B组与C组之间的C肽水平均存在显著差异。在这三组中，农村类型与热带型最为相似。
