Department of Periodontology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.
Center of Excellence in Periodontal Disease and Dental Implant, Chulalongkorn University, Bangkok, 10330, Thailand.
Clin Exp Dent Res. 2021 Aug;7(4):620-627. doi: 10.1002/cre2.372. Epub 2020 Dec 6.
To compare the efficacy of calcium sodium phosphosilicate (CSPS) and arginine dentifrices on dentin permeability and acid tolerance.
Sixty dentin discs were randomly assigned into 3 groups, then brushed for 1 min with CSPS, arginine, or fluoride (control) dentifrices. To test acid tolerance, each disc was soaked in 6% citric acid for 1 min. Dentin permeability was measured before, following brushing, and acid challenge. Ten discs per group were similarly treated and evaluated for tubule occlusion following a single dentifrice application, while other five discs per group were employed in an acid tolerance assay.
The percentage reduction in dentin permeability was 39.26%, 32.27%, and 21.71% in the arginine, CSPS, and control groups, respectively. The differences in dentin permeability reduction between the arginine and CSPS groups following brushing and acid challenge were not significant (p = 0.398 and p = 0.211, respectively). The arginine dentifrice demonstrated a significant reduction in permeability compared with the control (p = 0.011). In addition, the occlusion exhibited by the arginine and CSPS dentifrices was more resistant to acid challenge compared with that of the control (p < 0.001). From SEM analysis, dentinal tubule occlusion was observed after a single application in all groups. Some open dentinal tubules were detected in the test groups, while almost all of the orifices were open in the fluoride group following acid challenge.
There is no significant difference between arginine and CSPS dentifrices in reducing dentin permeability following a single application and acid challenge. Following acid challenge, the reduced permeability generated by arginine and CSPS was more stable compared with the fluoride dentifrice.
比较硅磷钙钠（CSPS）和精氨酸牙膏对牙本质通透性和耐酸性的疗效。
将 60 个牙本质圆盘随机分为 3 组，分别用 CSPS、精氨酸或氟化物（对照）牙膏刷牙 1 分钟。为了测试耐酸性，每个牙本质圆盘都浸泡在 6%柠檬酸中 1 分钟。在刷牙和酸蚀前、后测量牙本质通透性。每组 10 个牙本质圆盘采用相同的方法处理，并在单次使用牙膏后评估管腔闭塞情况，而每组的另外 5 个牙本质圆盘用于耐酸性检测。
精氨酸、CSPS 和对照组的牙本质通透性降低率分别为 39.26%、32.27%和 21.71%。刷牙和酸蚀后，精氨酸和 CSPS 组牙本质通透性降低率无显著差异（p=0.398 和 p=0.211）。与对照组相比，精氨酸牙膏可显著降低牙本质通透性（p=0.011）。此外，与对照组相比，精氨酸和 CSPS 牙膏的管腔闭塞更能耐受酸蚀（p<0.001）。从 SEM 分析来看，所有组在单次使用后均观察到牙本质小管闭塞。在测试组中发现一些开放的牙本质小管，而在酸蚀后，氟化物组几乎所有的牙本质小管开口都呈开放状态。
单次使用和酸蚀后，精氨酸和 CSPS 牙膏在降低牙本质通透性方面无显著差异。与氟化物牙膏相比，精氨酸和 CSPS 产生的通透性降低在酸蚀后更稳定。
