[多发性骨髓瘤与淋巴瘤患者血清IgG亚类分析及其与血细胞参数的相关性]
[Analysis of IgG Subclass in Blood Serum between Multiple Myeloma and Lymphoma Patients and Its Correlation with Blood Cell Parameters].
作者信息
Wang Jia-Qiang, Zhang Juan, Wang Zhi-Bin, Jiang Li
机构信息
Department of Laboratory Medicine, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, Chengdu 610072, Sichuan Province, China.
Department of Laboratory Medicine, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, Chengdu 610072, Sichuan Province, China,E-mail:
出版信息
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2020 Dec;28(6):1957-1961. doi: 10.19746/j.cnki.issn.1009-2137.2020.06.027.
OBJECTIVE
To investigate the expression of immunoglobulin G (IgG) and its subclasses in patients with multiple myeloma (MM) and lymphoma (LYM) and its correlation with blood cell parameters.
METHODS
129 patients with multiple myeloma and 113 patients with lymphoma diagnosed treated in Sichuan people's Hospital from January to December 2019 were selected and the total IgG and subclass IgG1, IgG2, IgG3 and IgG4, and some parameters of peripheral blood routine in patients were retrospective analyzed. Independent sample t test or nonparametric Mann Whitney U test were used for comparison between the groups. The relationship between IgG subclass and blood cell parameters was analyzed by correlation analysis. For the bivariate normal distribution data, Pearson correlation coefficient was calculated. For bivariate non normal distribution data, the Spearman correlation coefficient was calculated.
RESULTS
IgG1 and IgG2 were significantly higher in patients with multiple myeloma than in patients with lymphoma (P=0.001, 0.000, respectively), but IgG3 and IgG4 were significantly lower than in patients with lymphoma (P=0.000, 0.000, respectively), and there was no significant difference for total serum IgG between the two groups (P=0.717). The results showed that the IgG4 content of male patients with multiple myeloma and lymphoma was significantly higher than that of female patients (Z=-3.191, P=0.001); the age, M%, E% of the MM patients were significantly higher than those of the patients with lymphoma (P=0.000, 0.005, 0.019), but WBC, RBC, Hb were significantly lower than those of the patients with lymphoma (P=0.013, 0.000, respectively). The results of Spearman correlation analysis showed that RBC and Hb were decreased with the increasing of IgG and IgG1 in the MM patients(r=0.254, -0.272, -0.248 and -0.289, P=0.004, 0.002, 0.005 and 0.001). With the increasing of IgG4 in the serum of patients with lymphoma, RBC and Hb showed the trendy of decreased (r=-0.240 and, -0.251, respectively, P=0.010, 0.007).
CONCLUSION
The detection of IgG subclass and the correlation between IgG subclass and blood cell parameters are great value in the diagnosis and pathogenesis of multiple myeloma and lymphoma.
目的
探讨免疫球蛋白G（IgG）及其亚类在多发性骨髓瘤（MM）和淋巴瘤（LYM）患者中的表达情况及其与血细胞参数的相关性。
方法
选取2019年1月至12月在四川省人民医院确诊并接受治疗的129例多发性骨髓瘤患者和113例淋巴瘤患者，对患者的总IgG及IgG1、IgG2、IgG3和IgG4亚类，以及外周血常规的一些参数进行回顾性分析。组间比较采用独立样本t检验或非参数Mann Whitney U检验。通过相关性分析探讨IgG亚类与血细胞参数之间的关系。对于双变量正态分布数据，计算Pearson相关系数。对于双变量非正态分布数据，计算Spearman相关系数。
结果
多发性骨髓瘤患者的IgG1和IgG2显著高于淋巴瘤患者（分别为P = 0.001、0.000），但IgG3和IgG4显著低于淋巴瘤患者（分别为P = 0.000、0.000），两组患者血清总IgG差异无统计学意义（P = 0.717）。结果显示，多发性骨髓瘤和淋巴瘤男性患者的IgG4含量显著高于女性患者（Z = -3.191，P = 0.001）；MM患者的年龄、M%、E%显著高于淋巴瘤患者（P = 0.000、0.005、0.019），但白细胞、红细胞、血红蛋白显著低于淋巴瘤患者（分别为P = 0.013、0.000）。Spearman相关性分析结果显示，MM患者中红细胞和血红蛋白随IgG及IgG1升高而降低（r = 0.254、-0.272、-0.248和-0.289，P = 0.004、0.002、0.005和0.001）。淋巴瘤患者血清中IgG4升高时，红细胞和血红蛋白呈下降趋势（分别为r = -0.240和-0.251，P = 0.010、0.007）。
结论
IgG亚类检测及其与血细胞参数的相关性分析对多发性骨髓瘤和淋巴瘤的诊断及发病机制研究具有重要价值。
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