Reuter Matthew B, Hageman Kate, Waterman Rory
Department of Chemistry, University of Vermont, 82 University Place, 05405, Burlington, VT, USA.
Chemistry. 2021 Feb 15;27(10):3251-3261. doi: 10.1002/chem.202004555. Epub 2020 Dec 7.
Silicon-nitrogen bond formation is an important subfield in main group chemistry, and catalysis is an attractive route for efficient, selective formation of these bonds. Indeed, heterodehydrocoupling and N-silylation offer facile methods for the synthesis of small molecules through the coupling of primary, secondary, and tertiary silanes with N-containing substrates such as amines, carbazoles, indoles, and pyrroles. However, the reactivity of these catalytic systems is far from uniform, and critical issues are often encountered with product selectivity, conversions, substrate scope, catalyst activation, and in some instances, competing side reactions. Herein, a catalogue of catalysts and their reactivity for Si-N heterodehydrocoupling and N-silylation are reported.
硅氮键的形成是主族化学中的一个重要子领域，催化是高效、选择性地形成这些键的一条有吸引力的途径。实际上，杂脱氢偶联和N-硅烷化提供了通过伯、仲和叔硅烷与含氮底物（如胺、咔唑、吲哚和吡咯）偶联来合成小分子的简便方法。然而，这些催化体系的反应活性远非一致，在产物选择性、转化率、底物范围、催化剂活化以及某些情况下的竞争性副反应等方面经常会遇到关键问题。在此，报道了一系列用于硅氮杂脱氢偶联和N-硅烷化的催化剂及其反应活性。
