Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA.
Alzheimers Dement. 2021 May;17(5):745-754. doi: 10.1002/alz.12246. Epub 2020 Dec 7.
To test the association of vascular health (VH) across young adulthood with midlife dynamic cerebral autoregulation (dCA), gait, and cognition; and to test whether dCA is a modifying factor.
We studied 196 participants from the Coronary Artery Risk Development in Young Adults cohort who were followed over 30 years. VH was assessed at each visit according to American Heart Association recommendations. At year 30, dCA was measured using transcranial Doppler ultrasound and several gait and cognitive domains were assessed.
Worse VH from baseline through year 7, but not at year 30, was associated with less efficient dCA (all P < .05). Worse VH at all visits was associated with slower gait speed, and at year 7 with worse executive and global cognition (all P < .05). The association of baseline VH and midlife gait, but not cognition, was moderated by dCA (interaction P < .05).
VH as early as young adulthood may influence midlife brain health, and dCA may modify this relationship.
为了检验在整个青年期内血管健康（VH）与中年期动态脑自动调节（dCA）、步态和认知之间的关联，并检验 dCA 是否为调节因素。
我们研究了来自冠状动脉风险发展在年轻人队列的 196 名参与者，他们随访了 30 多年。根据美国心脏协会的建议，在每次就诊时评估 VH。在第 30 年，使用经颅多普勒超声测量 dCA，并评估了几个步态和认知领域。
从基线到第 7 年，而不是第 30 年，较差的 VH 与 dCA 效率降低相关（均 P < 0.05）。在所有就诊时，较差的 VH 与步行速度较慢相关，在第 7 年与执行和整体认知较差相关（均 P < 0.05）。dCA 调节了基线 VH 与中年步态的关系，但不调节认知（交互 P < 0.05）。
早在青年期的 VH 可能会影响中年期的大脑健康，而 dCA 可能会调节这种关系。
