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一名常染色体显性多囊肾病患者剖宫产术后疑似肺栓塞

Suspected Pulmonary Embolism Postcesarean Section in a Patient with Autosomal Dominant Polycystic Kidney Disease.

作者信息

Badejoko Olusegun O, Dada Olufunke F, Ubom Akaninyene E, Ajayeoba Olumuyiwa T

机构信息

Department of Obstetrics, Gynaecology and Perinatology, Obafemi Awolowo University, Ile-Ife, Nigeria.

Department of Obstetrics and Gynaecology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria.

出版信息

Niger Med J. 2020 Jul-Aug;61(4):223-225. doi: 10.4103/nmj.NMJ_99_20. Epub 2020 Aug 4.

Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetically inherited kidney disease worldwide. It is however relatively underdiagnosed in Africans because its diagnosis is often incidental. During pregnancy, ADPKD is associated with increased risk of preeclampsia and venous thromboembolism. The case of a 33-year-old lady incidentally diagnosed with ADPKD during pregnancy is presented. She developed preeclampsia at term and had cesarean delivery of twins. She however suffered cardiopulmonary arrest postoperatively and this created a treatment dilemma because therapeutic anticoagulation which was the primary treatment for her suspected pulmonary embolism was absolutely contraindicated if the actual cause of her collapse was ruptured cerebral aneurysm which was also a feature of ADPKD. We decided to resuscitate aggressively and perform an urgent cranial computed tomography which ruled out intracranial hemorrhage. We then commenced anticoagulation and she made an excellent recovery. This case illustrates the importance of a timely multidisciplinary approach to patient management.

摘要

常染色体显性多囊肾病(ADPKD)是全球最常见的遗传性肾病。然而,在非洲人中它相对诊断不足,因为其诊断往往是偶然的。在怀孕期间,ADPKD与子痫前期和静脉血栓栓塞风险增加有关。本文介绍了一位33岁女性在怀孕期间偶然诊断出ADPKD的病例。她足月时发生子痫前期并剖宫产下双胞胎。然而,她术后发生心肺骤停,这造成了治疗困境,因为如果她虚脱的实际原因是脑动脉瘤破裂(这也是ADPKD的一个特征),那么作为疑似肺栓塞主要治疗方法的治疗性抗凝是绝对禁忌的。我们决定积极进行复苏并紧急进行头颅计算机断层扫描,排除了颅内出血。然后我们开始抗凝治疗,她恢复得很好。这个病例说明了及时采取多学科方法进行患者管理的重要性。

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Sonographic analysis of adult polycystic kidney disease: retrospective data from South-East Nigeria.
Niger J Clin Pract. 2015 Mar-Apr;18(2):178-82. doi: 10.4103/1119-3077.151037.
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Pregnancy in chronic kidney disease.慢性肾脏病患者的妊娠问题。
Adv Chronic Kidney Dis. 2013 May;20(3):223-8. doi: 10.1053/j.ackd.2013.02.001.
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Fibrosis and progression of autosomal dominant polycystic kidney disease (ADPKD).常染色体显性多囊肾病(ADPKD)的纤维化与进展
Biochim Biophys Acta. 2011 Oct;1812(10):1327-36. doi: 10.1016/j.bbadis.2011.06.012. Epub 2011 Jul 1.
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