Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign.
Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign.
J Gerontol A Biol Sci Med Sci. 2021 Mar 31;76(4):586-590. doi: 10.1093/gerona/glaa308.
Anabolic resistance to a mechanical stimulus may contribute to the loss of skeletal muscle mass observed with age. In this study, young and aged mice were injected with saline or human LM-111 (1 mg/kg). One week later, the myotendinous junction of the gastrocnemius muscle was removed via myotenectomy (MTE), thus placing a chronic mechanical stimulus on the remaining plantaris muscle for 2 weeks. LM-111 increased α7B integrin protein expression and clustering of the α7B integrin near DAPI+ nuclei in aged muscle in response to MTE. LM-111 reduced CD11b+ immune cells, enhanced repair, and improved the growth response to loading in aged plantaris muscle. These results suggest that LM-111 may represent a novel therapeutic approach to prevent and/or treat sarcopenia.
肌肉对机械刺激的合成代谢抵抗可能导致与年龄相关的骨骼肌质量下降。在这项研究中，年轻和老年小鼠分别注射生理盐水或人 LM-111（1mg/kg）。一周后，通过肌切开术（MTE）切除比目鱼肌的肌腱连接，从而对剩余的跖肌施加慢性机械刺激 2 周。LM-111 增加了 α7B 整合素蛋白的表达，并在 MTE 后使 α7B 整合素在 DAPI+核附近聚集。LM-111 减少了 CD11b+免疫细胞，增强了修复，并改善了老年跖肌对负荷的生长反应。这些结果表明，LM-111 可能代表一种预防和/或治疗肌肉减少症的新的治疗方法。
