基因转移可恢复性腺功能减退小鼠的性腺发育和配子发生。

Gonadal development and gametogenesis in the hypogonadal mouse are restored by gene transfer.

作者信息

Mason A J, Pitts S L, Nikolics K, Szonyi E, Wilcox J N, Seeburg P H, Stewart T A

机构信息

Department of Developmental Biology, Genentech, Inc., South San Francisco, California 94080.

出版信息

Ann N Y Acad Sci. 1987;513:16-26. doi: 10.1111/j.1749-6632.1987.tb24995.x.

DOI:10.1111/j.1749-6632.1987.tb24995.x

PMID:3328535

Abstract

These results describe controlled regulation of a mammalian neural gene in transgenic mice. Analysis of truncated GnRH-GAP genes in transgenic mice will enable us to define the DNA sequences responsible for this control. Furthermore, by separate mutation of the GnRH and GAP coding sequences we will be able to determine the relative importance of these two peptides in the development and maintenance of reproductive function.

摘要

这些结果描述了转基因小鼠中哺乳动物神经基因的可控调节。对转基因小鼠中截短的促性腺激素释放激素 - GAP基因的分析将使我们能够确定负责这种控制的DNA序列。此外，通过分别对促性腺激素释放激素和GAP编码序列进行突变，我们将能够确定这两种肽在生殖功能的发育和维持中的相对重要性。