在 CFN-MPS200 上自动化生产[F]MK-6240。
Automated production of [F]MK-6240 on CFN-MPS200.
机构信息
Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo, 173-0015, Japan.
SHI Accelerator Services, 1-7-16 Osaki, Shinagawa-ku, Tokyo, 141-0032, Japan.
出版信息
Appl Radiat Isot. 2021 Feb;168:109468. doi: 10.1016/j.apradiso.2020.109468. Epub 2020 Nov 24.
Automated production of [F]MK-6240 was implemented for the first time in the CFN-MPS200 module. Three consecutive productions of [F]MK-6240 complied with the product specifications. Formulated [F]MK-6240 maintained stability, as measured by radio-high-performance liquid chromatography (HPLC), as well as clarity and pH, over a period of 8 h. Our established method can facilitate multi-center trials and widespread use of [F]MK-6240.
首次在 CFN-MPS200 模块中实现了[F]MK-6240 的自动化生产。三次连续生产的[F]MK-6240 均符合产品规格。经测定，制剂[F]MK-6240 在 8 小时内保持稳定，其无线电高效液相色谱（HPLC）以及澄清度和 pH 值均符合要求。我们建立的方法可以促进[F]MK-6240 的多中心试验和广泛应用。
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